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Clinical Subgroups in Bilateral Meniere Disease
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075646/ https://www.ncbi.nlm.nih.gov/pubmed/27822199 http://dx.doi.org/10.3389/fneur.2016.00182 |
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author | Frejo, Lidia Soto-Varela, Andres Santos-Perez, Sofía Aran, Ismael Batuecas-Caletrio, Angel Perez-Guillen, Vanesa Perez-Garrigues, Herminio Fraile, Jesus Martin-Sanz, Eduardo Tapia, Maria C. Trinidad, Gabriel García-Arumi, Ana María González-Aguado, Rocío Espinosa-Sanchez, Juan M. Marques, Pedro Perez, Paz Benitez, Jesus Lopez-Escamez, Jose A. |
author_facet | Frejo, Lidia Soto-Varela, Andres Santos-Perez, Sofía Aran, Ismael Batuecas-Caletrio, Angel Perez-Guillen, Vanesa Perez-Garrigues, Herminio Fraile, Jesus Martin-Sanz, Eduardo Tapia, Maria C. Trinidad, Gabriel García-Arumi, Ana María González-Aguado, Rocío Espinosa-Sanchez, Juan M. Marques, Pedro Perez, Paz Benitez, Jesus Lopez-Escamez, Jose A. |
author_sort | Frejo, Lidia |
collection | PubMed |
description | Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD. |
format | Online Article Text |
id | pubmed-5075646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50756462016-11-07 Clinical Subgroups in Bilateral Meniere Disease Frejo, Lidia Soto-Varela, Andres Santos-Perez, Sofía Aran, Ismael Batuecas-Caletrio, Angel Perez-Guillen, Vanesa Perez-Garrigues, Herminio Fraile, Jesus Martin-Sanz, Eduardo Tapia, Maria C. Trinidad, Gabriel García-Arumi, Ana María González-Aguado, Rocío Espinosa-Sanchez, Juan M. Marques, Pedro Perez, Paz Benitez, Jesus Lopez-Escamez, Jose A. Front Neurol Neuroscience Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD. Frontiers Media S.A. 2016-10-24 /pmc/articles/PMC5075646/ /pubmed/27822199 http://dx.doi.org/10.3389/fneur.2016.00182 Text en Copyright © 2016 Frejo, Soto-Varela, Santos-Perez, Aran, Batuecas-Caletrio, Perez-Guillen, Perez-Garrigues, Fraile, Martin-Sanz, Tapia, Trinidad, García-Arumi, González-Aguado, Espinosa-Sanchez, Marques, Perez, Benitez and Lopez-Escamez On Behalf of the Meniere’s Disease Consortium (MeDiC). http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Frejo, Lidia Soto-Varela, Andres Santos-Perez, Sofía Aran, Ismael Batuecas-Caletrio, Angel Perez-Guillen, Vanesa Perez-Garrigues, Herminio Fraile, Jesus Martin-Sanz, Eduardo Tapia, Maria C. Trinidad, Gabriel García-Arumi, Ana María González-Aguado, Rocío Espinosa-Sanchez, Juan M. Marques, Pedro Perez, Paz Benitez, Jesus Lopez-Escamez, Jose A. Clinical Subgroups in Bilateral Meniere Disease |
title | Clinical Subgroups in Bilateral Meniere Disease |
title_full | Clinical Subgroups in Bilateral Meniere Disease |
title_fullStr | Clinical Subgroups in Bilateral Meniere Disease |
title_full_unstemmed | Clinical Subgroups in Bilateral Meniere Disease |
title_short | Clinical Subgroups in Bilateral Meniere Disease |
title_sort | clinical subgroups in bilateral meniere disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075646/ https://www.ncbi.nlm.nih.gov/pubmed/27822199 http://dx.doi.org/10.3389/fneur.2016.00182 |
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