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Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?

Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protectiv...

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Autores principales: Liang, Li-jun, Yang, Jin-ming, Jin, Xin-chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075681/
https://www.ncbi.nlm.nih.gov/pubmed/27826421
http://dx.doi.org/10.4103/2045-9912.179343
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author Liang, Li-jun
Yang, Jin-ming
Jin, Xin-chun
author_facet Liang, Li-jun
Yang, Jin-ming
Jin, Xin-chun
author_sort Liang, Li-jun
collection PubMed
description Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protective agents targeting ischemia and reperfusion respectively may obtain substantially better results than a single agent. Normobaric hyperoxia (NBO) has been shown to exhibit neuro- and vaso-protective effects by improving tissue oxygenation when it is given during ischemia, however the effect of NBO would diminish when the duration of ischemia and reperfusion was extended. Therefore, during reperfusion drug treatment targeting inflammation, oxidative stress and free radical scavenger would be a useful adjuvant to extend the therapeutic window of tissue plasminogen activator, the only United States Food and Drug Administration (FDA) approved treatment for acute ischemic stroke. In this review, we discussed the neuro- and vaso-protective effects of NBO and recent finding of combining NBO with other drugs.
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spelling pubmed-50756812016-11-08 Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke? Liang, Li-jun Yang, Jin-ming Jin, Xin-chun Med Gas Res Review Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protective agents targeting ischemia and reperfusion respectively may obtain substantially better results than a single agent. Normobaric hyperoxia (NBO) has been shown to exhibit neuro- and vaso-protective effects by improving tissue oxygenation when it is given during ischemia, however the effect of NBO would diminish when the duration of ischemia and reperfusion was extended. Therefore, during reperfusion drug treatment targeting inflammation, oxidative stress and free radical scavenger would be a useful adjuvant to extend the therapeutic window of tissue plasminogen activator, the only United States Food and Drug Administration (FDA) approved treatment for acute ischemic stroke. In this review, we discussed the neuro- and vaso-protective effects of NBO and recent finding of combining NBO with other drugs. Medknow Publications & Media Pvt Ltd 2016-04-04 /pmc/articles/PMC5075681/ /pubmed/27826421 http://dx.doi.org/10.4103/2045-9912.179343 Text en Copyright: © 2016 Medical Gas Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review
Liang, Li-jun
Yang, Jin-ming
Jin, Xin-chun
Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title_full Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title_fullStr Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title_full_unstemmed Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title_short Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
title_sort cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075681/
https://www.ncbi.nlm.nih.gov/pubmed/27826421
http://dx.doi.org/10.4103/2045-9912.179343
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