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Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database
INTRODUCTION: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International AIDS Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075717/ https://www.ncbi.nlm.nih.gov/pubmed/27774955 http://dx.doi.org/10.7448/IAS.19.1.20965 |
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author | Ahn, Jin Young Boettiger, David Kiertiburanakul, Sasisopin Merati, Tuti Parwati Huy, Bui Vu Wong, Wing Wai Ditangco, Rossana Lee, Man Po Oka, Shinichi Durier, Nicolas Choi, Jun Yong |
author_facet | Ahn, Jin Young Boettiger, David Kiertiburanakul, Sasisopin Merati, Tuti Parwati Huy, Bui Vu Wong, Wing Wai Ditangco, Rossana Lee, Man Po Oka, Shinichi Durier, Nicolas Choi, Jun Yong |
author_sort | Ahn, Jin Young |
collection | PubMed |
description | INTRODUCTION: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. METHODS: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. RESULTS: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88–6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69–7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706–0.997) were significantly associated with syphilis seroconversion. CONCLUSIONS: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population. |
format | Online Article Text |
id | pubmed-5075717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International AIDS Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-50757172016-10-27 Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database Ahn, Jin Young Boettiger, David Kiertiburanakul, Sasisopin Merati, Tuti Parwati Huy, Bui Vu Wong, Wing Wai Ditangco, Rossana Lee, Man Po Oka, Shinichi Durier, Nicolas Choi, Jun Yong J Int AIDS Soc Research Article INTRODUCTION: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. METHODS: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. RESULTS: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88–6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69–7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706–0.997) were significantly associated with syphilis seroconversion. CONCLUSIONS: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population. International AIDS Society 2016-10-21 /pmc/articles/PMC5075717/ /pubmed/27774955 http://dx.doi.org/10.7448/IAS.19.1.20965 Text en © 2016 Ahn JY et al; licensee International AIDS Society http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ahn, Jin Young Boettiger, David Kiertiburanakul, Sasisopin Merati, Tuti Parwati Huy, Bui Vu Wong, Wing Wai Ditangco, Rossana Lee, Man Po Oka, Shinichi Durier, Nicolas Choi, Jun Yong Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title | Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title_full | Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title_fullStr | Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title_full_unstemmed | Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title_short | Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database |
title_sort | incidence of syphilis seroconversion among hiv-infected persons in asia: results from the treat asia hiv observational database |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075717/ https://www.ncbi.nlm.nih.gov/pubmed/27774955 http://dx.doi.org/10.7448/IAS.19.1.20965 |
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