The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency

Although activation of the ErbB family of receptor tyrosine kinases (ErbB1-4) is driven by oligomerization mediated by intermolecular interactions between the extracellular, the kinase and the transmembrane domains, the transmembrane domain has been largely neglected in this regard. The largest cont...

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Detalles Bibliográficos
Autores principales: Kovács, Tamás, Batta, Gyula, Hajdu, Tímea, Szabó, Ágnes, Váradi, Tímea, Zákány, Florina, Csomós, István, Szöllősi, János, Nagy, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075772/
https://www.ncbi.nlm.nih.gov/pubmed/27775011
http://dx.doi.org/10.1038/srep35850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075772/
https://www.ncbi.nlm.nih.gov/pubmed/27775011
http://dx.doi.org/10.1038/srep35850

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