Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) and inhibition (DSI). 2-AG is degraded primarily by monoacylglycerol lipase (MAGL), which is expressed in neurons and astrocytes. Using knockout...

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Detalles Bibliográficos
Autores principales: Liu, Xiaojie, Chen, Yao, Vickstrom, Casey R., Li, Yan, Viader, Andreu, Cravatt, Benjamin F., Liu, Qing-song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075776/
https://www.ncbi.nlm.nih.gov/pubmed/27775008
http://dx.doi.org/10.1038/srep35829

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