SIKs control osteocyte responses to parathyroid hormone

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducib...

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Detalles Bibliográficos
Autores principales: Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O'Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J., Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075806/
https://www.ncbi.nlm.nih.gov/pubmed/27759007
http://dx.doi.org/10.1038/ncomms13176

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