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Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity
Clinical development of Chk1 inhibitors is currently focussed on evaluating activity as monotherapy and as potentiators of chemotherapy. To aid translation of pre-clinical studies, we sought to understand the effects of the tumour growth environment on Chk1 signalling and sensitivity to small molecu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075878/ https://www.ncbi.nlm.nih.gov/pubmed/27775084 http://dx.doi.org/10.1038/srep35874 |