Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury

Thromboxane A2 receptor (TXA2R) activation is thought to be involved in thrombosis/hemostasis and inflammation responses. We have previously shown that TXA2R antagonist SQ29548 attenuates BV2 microglia activation by suppression of ERK pathway, but its effect is not tested in vivo. The present study...

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Detalles Bibliográficos
Autores principales: Yan, Aijuan, Zhang, Tingting, Yang, Xiao, Shao, Jiaxiang, Fu, Ningzhen, Shen, Fanxia, Fu, Yi, Xia, Weiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075919/
https://www.ncbi.nlm.nih.gov/pubmed/27775054
http://dx.doi.org/10.1038/srep35885

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