Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression

AMPD1 is an adenosine monophosphate deaminase that catalyzes the deamination of AMP to IMP. To understand the physiological function of AMPD1, we obtained a strain of Ampd1 mutant mice from KOMP repository, which was generated by a knockout-first strategy. An elevated AMP level and almost complete l...

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Detalles Bibliográficos
Autores principales: Pan, Yongcheng, Zhang, Lusi, Liu, Qiong, Li, Ying, Guo, Hui, Peng, Yu, Peng, Hexiang, Tang, Beisha, Hu, Zhengmao, Zhao, Jingping, Xia, Kun, Li, Jia-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075929/
https://www.ncbi.nlm.nih.gov/pubmed/27775065
http://dx.doi.org/10.1038/srep35970

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