Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu(2−X)Te) nanocubes (NCs) as...

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Autores principales: Poulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M. Sheikh, Aburto, Rebeca Romero, Mitcham, Trevor, Bouchard, Richard R., Ajayan, Pulickel M., Sakamoto, Yasushi, Maekawa, Toru, Kumar, D. Sakthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075932/
https://www.ncbi.nlm.nih.gov/pubmed/27775048
http://dx.doi.org/10.1038/srep35961
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author Poulose, Aby Cheruvathoor
Veeranarayanan, Srivani
Mohamed, M. Sheikh
Aburto, Rebeca Romero
Mitcham, Trevor
Bouchard, Richard R.
Ajayan, Pulickel M.
Sakamoto, Yasushi
Maekawa, Toru
Kumar, D. Sakthi
author_facet Poulose, Aby Cheruvathoor
Veeranarayanan, Srivani
Mohamed, M. Sheikh
Aburto, Rebeca Romero
Mitcham, Trevor
Bouchard, Richard R.
Ajayan, Pulickel M.
Sakamoto, Yasushi
Maekawa, Toru
Kumar, D. Sakthi
author_sort Poulose, Aby Cheruvathoor
collection PubMed
description Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu(2−X)Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.
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spelling pubmed-50759322016-10-28 Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453 Poulose, Aby Cheruvathoor Veeranarayanan, Srivani Mohamed, M. Sheikh Aburto, Rebeca Romero Mitcham, Trevor Bouchard, Richard R. Ajayan, Pulickel M. Sakamoto, Yasushi Maekawa, Toru Kumar, D. Sakthi Sci Rep Article Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu(2−X)Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies. Nature Publishing Group 2016-10-24 /pmc/articles/PMC5075932/ /pubmed/27775048 http://dx.doi.org/10.1038/srep35961 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Poulose, Aby Cheruvathoor
Veeranarayanan, Srivani
Mohamed, M. Sheikh
Aburto, Rebeca Romero
Mitcham, Trevor
Bouchard, Richard R.
Ajayan, Pulickel M.
Sakamoto, Yasushi
Maekawa, Toru
Kumar, D. Sakthi
Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title_full Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title_fullStr Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title_full_unstemmed Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title_short Multifunctional Cu(2−x)Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
title_sort multifunctional cu(2−x)te nanocubes mediated combination therapy for multi-drug resistant mda mb 453
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075932/
https://www.ncbi.nlm.nih.gov/pubmed/27775048
http://dx.doi.org/10.1038/srep35961
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