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Clinical Features and Prognosis of Herpetic Anterior Uveitis
OBJECTIVE: To evaluate clinical features, complications, visual outcomes and treatment modalities in patients clinically diagnosed with herpetic anterior uveitis (AU). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 67 patients seen at the Umraniye Training and Research Hos...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076292/ https://www.ncbi.nlm.nih.gov/pubmed/27800272 http://dx.doi.org/10.4274/tjo.92053 |
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author | Kardeş, Esra Bozkurt, Kansu Sezgin Akçay, Betül İlkay Ünlü, Cihan Aydoğan Gezginaslan, Tuğba Ergin, Ahmet |
author_facet | Kardeş, Esra Bozkurt, Kansu Sezgin Akçay, Betül İlkay Ünlü, Cihan Aydoğan Gezginaslan, Tuğba Ergin, Ahmet |
author_sort | Kardeş, Esra |
collection | PubMed |
description | OBJECTIVE: To evaluate clinical features, complications, visual outcomes and treatment modalities in patients clinically diagnosed with herpetic anterior uveitis (AU). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 67 patients seen at the Umraniye Training and Research Hospital, Ophthalmology Clinic, Uveitis and Cornea Department from January 2009 to June 2013. RESULTS: Thirty-seven patients (55.2%) were female and 30 (44.7%) patients were male. The average follow-up period was 12.9 ± 10.6 months (range: 1-45 months). The most common ocular findings were granulomatous keratic precipitates (KPs) (82.2%), corneal involvement (62.6%), iris atrophy (41.7%) and transient elevated intraocular pressure (IOP) (40.2%). Recurrences were observed in 46.2% of the eyes and the median recurrence rate was 1.0 during the follow-up period. Topical steroids and oral antiviral (acyclovir) therapy were applied to all patients during active episodes. Long-term oral acyclovir was used in 29.8% of the patients. Recurrence rates were significantly lower in patients who used oral acyclovir for more than 6 months, whereas complications rates and final visual acuity did not show any difference between groups. Final visual acuity was better than 20/40 in 61.1% of eyes, and visual impairment was due to corneal scarring or cataract formation. CONCLUSION: Herpetic AU can present with or without corneal involvement. Granulomatous KPs, iris atrophy and elevated IOP are important clinical findings for the diagnosis of cases without corneal involvement. Long-term oral acyclovir treatment (more than 6 months) and is important to decrease recurrence rates and possible complications. Visual prognosis is favorable in cases without corneal scarring. |
format | Online Article Text |
id | pubmed-5076292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-50762922016-10-31 Clinical Features and Prognosis of Herpetic Anterior Uveitis Kardeş, Esra Bozkurt, Kansu Sezgin Akçay, Betül İlkay Ünlü, Cihan Aydoğan Gezginaslan, Tuğba Ergin, Ahmet Turk J Ophthalmol Original Article OBJECTIVE: To evaluate clinical features, complications, visual outcomes and treatment modalities in patients clinically diagnosed with herpetic anterior uveitis (AU). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 67 patients seen at the Umraniye Training and Research Hospital, Ophthalmology Clinic, Uveitis and Cornea Department from January 2009 to June 2013. RESULTS: Thirty-seven patients (55.2%) were female and 30 (44.7%) patients were male. The average follow-up period was 12.9 ± 10.6 months (range: 1-45 months). The most common ocular findings were granulomatous keratic precipitates (KPs) (82.2%), corneal involvement (62.6%), iris atrophy (41.7%) and transient elevated intraocular pressure (IOP) (40.2%). Recurrences were observed in 46.2% of the eyes and the median recurrence rate was 1.0 during the follow-up period. Topical steroids and oral antiviral (acyclovir) therapy were applied to all patients during active episodes. Long-term oral acyclovir was used in 29.8% of the patients. Recurrence rates were significantly lower in patients who used oral acyclovir for more than 6 months, whereas complications rates and final visual acuity did not show any difference between groups. Final visual acuity was better than 20/40 in 61.1% of eyes, and visual impairment was due to corneal scarring or cataract formation. CONCLUSION: Herpetic AU can present with or without corneal involvement. Granulomatous KPs, iris atrophy and elevated IOP are important clinical findings for the diagnosis of cases without corneal involvement. Long-term oral acyclovir treatment (more than 6 months) and is important to decrease recurrence rates and possible complications. Visual prognosis is favorable in cases without corneal scarring. Galenos Publishing 2016-06 2016-06-06 /pmc/articles/PMC5076292/ /pubmed/27800272 http://dx.doi.org/10.4274/tjo.92053 Text en ©Turkish Journal of Ophthalmology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kardeş, Esra Bozkurt, Kansu Sezgin Akçay, Betül İlkay Ünlü, Cihan Aydoğan Gezginaslan, Tuğba Ergin, Ahmet Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title | Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title_full | Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title_fullStr | Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title_full_unstemmed | Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title_short | Clinical Features and Prognosis of Herpetic Anterior Uveitis |
title_sort | clinical features and prognosis of herpetic anterior uveitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076292/ https://www.ncbi.nlm.nih.gov/pubmed/27800272 http://dx.doi.org/10.4274/tjo.92053 |
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