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Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points acc...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076302/ https://www.ncbi.nlm.nih.gov/pubmed/27800249 http://dx.doi.org/10.4274/tjo.48902 |
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author | Kılıç Müftüoğlu, İlkay Aydın Akova, Yonca |
author_facet | Kılıç Müftüoğlu, İlkay Aydın Akova, Yonca |
author_sort | Kılıç Müftüoğlu, İlkay |
collection | PubMed |
description | OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer’s test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients. Additional treatments were given as needed. Complications were recorded. RESULTS: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocular findings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalazia in 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvement of symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer’s test and BUT were 3.3±1.5 and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved in both eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patients showed significant regression of corneal neovascularization with topical bevacizumab therapy. CONCLUSION: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease with appropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline. |
format | Online Article Text |
id | pubmed-5076302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-50763022016-10-31 Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea Kılıç Müftüoğlu, İlkay Aydın Akova, Yonca Turk J Ophthalmol Original Article OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer’s test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients. Additional treatments were given as needed. Complications were recorded. RESULTS: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocular findings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalazia in 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvement of symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer’s test and BUT were 3.3±1.5 and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved in both eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patients showed significant regression of corneal neovascularization with topical bevacizumab therapy. CONCLUSION: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease with appropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline. Galenos Publishing 2016-01 2016-01-05 /pmc/articles/PMC5076302/ /pubmed/27800249 http://dx.doi.org/10.4274/tjo.48902 Text en ©Turkish Journal of Ophthalmology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kılıç Müftüoğlu, İlkay Aydın Akova, Yonca Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title | Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title_full | Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title_fullStr | Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title_full_unstemmed | Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title_short | Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea |
title_sort | clinical findings, follow-up and treatment results in patients with ocular rosacea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076302/ https://www.ncbi.nlm.nih.gov/pubmed/27800249 http://dx.doi.org/10.4274/tjo.48902 |
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