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Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea

OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points acc...

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Autores principales: Kılıç Müftüoğlu, İlkay, Aydın Akova, Yonca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076302/
https://www.ncbi.nlm.nih.gov/pubmed/27800249
http://dx.doi.org/10.4274/tjo.48902
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author Kılıç Müftüoğlu, İlkay
Aydın Akova, Yonca
author_facet Kılıç Müftüoğlu, İlkay
Aydın Akova, Yonca
author_sort Kılıç Müftüoğlu, İlkay
collection PubMed
description OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer’s test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients. Additional treatments were given as needed. Complications were recorded. RESULTS: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocular findings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalazia in 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvement of symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer’s test and BUT were 3.3±1.5 and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved in both eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patients showed significant regression of corneal neovascularization with topical bevacizumab therapy. CONCLUSION: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease with appropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline.
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spelling pubmed-50763022016-10-31 Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea Kılıç Müftüoğlu, İlkay Aydın Akova, Yonca Turk J Ophthalmol Original Article OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients’ ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer’s test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients. Additional treatments were given as needed. Complications were recorded. RESULTS: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocular findings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalazia in 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvement of symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer’s test and BUT were 3.3±1.5 and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved in both eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patients showed significant regression of corneal neovascularization with topical bevacizumab therapy. CONCLUSION: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease with appropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline. Galenos Publishing 2016-01 2016-01-05 /pmc/articles/PMC5076302/ /pubmed/27800249 http://dx.doi.org/10.4274/tjo.48902 Text en ©Turkish Journal of Ophthalmology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kılıç Müftüoğlu, İlkay
Aydın Akova, Yonca
Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title_full Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title_fullStr Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title_full_unstemmed Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title_short Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea
title_sort clinical findings, follow-up and treatment results in patients with ocular rosacea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076302/
https://www.ncbi.nlm.nih.gov/pubmed/27800249
http://dx.doi.org/10.4274/tjo.48902
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