Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain

Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like growth factors (IGF)-I/II are major growth factors....

Descripción completa

Detalles Bibliográficos
Autores principales: Hexnerová, Rozálie, Křížková, Květoslava, Fábry, Milan, Sieglová, Irena, Kedrová, Kateřina, Collinsová, Michaela, Ullrichová, Pavlína, Srb, Pavel, Williams, Christopher, Crump, Matthew P., Tošner, Zdeněk, Jiráček, Jiří, Veverka, Václav, Žáková, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076530/
https://www.ncbi.nlm.nih.gov/pubmed/27510031
http://dx.doi.org/10.1074/jbc.M116.741041

Ejemplares similares

Ejemplares similares