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Helicobacter pylori and gastric acid: an intimate and reciprocal relationship

Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect. The...

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Detalles Bibliográficos
Autores principales: Waldum, Helge L., Kleveland, Per M., Sørdal, Øystein F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076771/
https://www.ncbi.nlm.nih.gov/pubmed/27803738
http://dx.doi.org/10.1177/1756283X16663395
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author Waldum, Helge L.
Kleveland, Per M.
Sørdal, Øystein F.
author_facet Waldum, Helge L.
Kleveland, Per M.
Sørdal, Øystein F.
author_sort Waldum, Helge L.
collection PubMed
description Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect. The initial infection seems to require a temporal gastric hypoacidity. For Hp to survive in the gastric mucous layer, some acidity is necessary. Hp itself is probably not directly carcinogenic. Only when inducing oxyntic mucosal inflammation and atrophy with hypoacidity, Hp predisposes for gastric cancer. Gastrin most likely plays a central role in the Hp pathogenesis of duodenal ulcer and gastric cancer.
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spelling pubmed-50767712016-11-02 Helicobacter pylori and gastric acid: an intimate and reciprocal relationship Waldum, Helge L. Kleveland, Per M. Sørdal, Øystein F. Therap Adv Gastroenterol Reviews Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect. The initial infection seems to require a temporal gastric hypoacidity. For Hp to survive in the gastric mucous layer, some acidity is necessary. Hp itself is probably not directly carcinogenic. Only when inducing oxyntic mucosal inflammation and atrophy with hypoacidity, Hp predisposes for gastric cancer. Gastrin most likely plays a central role in the Hp pathogenesis of duodenal ulcer and gastric cancer. SAGE Publications 2016-08-23 2016-11 /pmc/articles/PMC5076771/ /pubmed/27803738 http://dx.doi.org/10.1177/1756283X16663395 Text en © The Author(s), 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Waldum, Helge L.
Kleveland, Per M.
Sørdal, Øystein F.
Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title_full Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title_fullStr Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title_full_unstemmed Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title_short Helicobacter pylori and gastric acid: an intimate and reciprocal relationship
title_sort helicobacter pylori and gastric acid: an intimate and reciprocal relationship
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076771/
https://www.ncbi.nlm.nih.gov/pubmed/27803738
http://dx.doi.org/10.1177/1756283X16663395
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