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Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE

GlgE is a maltosyltransferase involved in α-glucan biosynthesis in bacteria that has been genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium tuberculosis enzyme diffract at low resolution so most structural studies have been with the very similar Streptomyces...

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Detalles Bibliográficos
Autores principales:	Syson, Karl, Stevenson, Clare E. M., Miah, Farzana, Barclay, J. Elaine, Tang, Minhong, Gorelik, Andrii, Rashid, Abdul M., Lawson, David M., Bornemann, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076824/ https://www.ncbi.nlm.nih.gov/pubmed/27531751 http://dx.doi.org/10.1074/jbc.M116.748160

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