Cargando…

Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes

PURPOSE: The purpose of our study is to correlate quantitatively measured tumor stiffness with immunohistochemical (IHC) subtypes of breast cancer. Additionally, the influence of prognostic histologic features (cancer grade, size, lymph node status, and histological type and grade) to the tumor elas...

Descripción completa

Detalles Bibliográficos
Autores principales: Denis, Max, Gregory, Adriana, Bayat, Mahdi, Fazzio, Robert T., Whaley, Dana H., Ghosh, Karthik, Shah, Sejal, Fatemi, Mostafa, Alizad, Azra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077080/
https://www.ncbi.nlm.nih.gov/pubmed/27776153
http://dx.doi.org/10.1371/journal.pone.0165003
_version_ 1782462127424929792
author Denis, Max
Gregory, Adriana
Bayat, Mahdi
Fazzio, Robert T.
Whaley, Dana H.
Ghosh, Karthik
Shah, Sejal
Fatemi, Mostafa
Alizad, Azra
author_facet Denis, Max
Gregory, Adriana
Bayat, Mahdi
Fazzio, Robert T.
Whaley, Dana H.
Ghosh, Karthik
Shah, Sejal
Fatemi, Mostafa
Alizad, Azra
author_sort Denis, Max
collection PubMed
description PURPOSE: The purpose of our study is to correlate quantitatively measured tumor stiffness with immunohistochemical (IHC) subtypes of breast cancer. Additionally, the influence of prognostic histologic features (cancer grade, size, lymph node status, and histological type and grade) to the tumor elasticity and IHC profile relationship will be investigated. METHODS: Under an institutional review board (IRB) approved protocol, B-mode ultrasound (US) and comb-push ultrasound shear elastography (CUSE) were performed on 157 female patients with suspicious breast lesions. Out of 157 patients 83 breast cancer patients confirmed by pathology were included in this study. The association between CUSE mean stiffness values and the aforementioned prognostic features of the breast cancer tumors were investigated. RESULTS: Our results demonstrate that the most statistically significant difference (p = 0.0074) with mean elasticity is tumor size. When considering large tumors (size ≥ 8mm), thus minimizing the statistical significance of tumor size, a significant difference (p< 0.05) with mean elasticity is obtained between luminal A of histological grade I and luminal B (Ki-67 > 20%) subtypes. CONCLUSION: Tumor size is an independent factor influencing mean elasticity. The Ki-67 proliferation index and histological grade were dependent factors influencing mean elasticity for the differentiation between luminal subtypes. Future studies on a larger group of patients may broaden the clinical significance of these findings.
format Online
Article
Text
id pubmed-5077080
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-50770802016-11-04 Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes Denis, Max Gregory, Adriana Bayat, Mahdi Fazzio, Robert T. Whaley, Dana H. Ghosh, Karthik Shah, Sejal Fatemi, Mostafa Alizad, Azra PLoS One Research Article PURPOSE: The purpose of our study is to correlate quantitatively measured tumor stiffness with immunohistochemical (IHC) subtypes of breast cancer. Additionally, the influence of prognostic histologic features (cancer grade, size, lymph node status, and histological type and grade) to the tumor elasticity and IHC profile relationship will be investigated. METHODS: Under an institutional review board (IRB) approved protocol, B-mode ultrasound (US) and comb-push ultrasound shear elastography (CUSE) were performed on 157 female patients with suspicious breast lesions. Out of 157 patients 83 breast cancer patients confirmed by pathology were included in this study. The association between CUSE mean stiffness values and the aforementioned prognostic features of the breast cancer tumors were investigated. RESULTS: Our results demonstrate that the most statistically significant difference (p = 0.0074) with mean elasticity is tumor size. When considering large tumors (size ≥ 8mm), thus minimizing the statistical significance of tumor size, a significant difference (p< 0.05) with mean elasticity is obtained between luminal A of histological grade I and luminal B (Ki-67 > 20%) subtypes. CONCLUSION: Tumor size is an independent factor influencing mean elasticity. The Ki-67 proliferation index and histological grade were dependent factors influencing mean elasticity for the differentiation between luminal subtypes. Future studies on a larger group of patients may broaden the clinical significance of these findings. Public Library of Science 2016-10-24 /pmc/articles/PMC5077080/ /pubmed/27776153 http://dx.doi.org/10.1371/journal.pone.0165003 Text en © 2016 Denis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Denis, Max
Gregory, Adriana
Bayat, Mahdi
Fazzio, Robert T.
Whaley, Dana H.
Ghosh, Karthik
Shah, Sejal
Fatemi, Mostafa
Alizad, Azra
Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title_full Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title_fullStr Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title_full_unstemmed Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title_short Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
title_sort correlating tumor stiffness with immunohistochemical subtypes of breast cancers: prognostic value of comb-push ultrasound shear elastography for differentiating luminal subtypes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077080/
https://www.ncbi.nlm.nih.gov/pubmed/27776153
http://dx.doi.org/10.1371/journal.pone.0165003
work_keys_str_mv AT denismax correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT gregoryadriana correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT bayatmahdi correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT fazziorobertt correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT whaleydanah correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT ghoshkarthik correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT shahsejal correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT fatemimostafa correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes
AT alizadazra correlatingtumorstiffnesswithimmunohistochemicalsubtypesofbreastcancersprognosticvalueofcombpushultrasoundshearelastographyfordifferentiatingluminalsubtypes