Cargando…

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway

The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is well known to transit to the en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tam, Joshua H. K., Cobb, M. Rebecca, Seah, Claudia, Pasternak, Stephen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077117/ https://www.ncbi.nlm.nih.gov/pubmed/27776132 http://dx.doi.org/10.1371/journal.pone.0161445

Ejemplares similares

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
por: Tam, Joshua HK, et al.
Publicado: (2014)

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes
por: Tang, Weihao, et al.
Publicado: (2015)

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
por: Yang, Miao, et al.
Publicado: (2013)

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
por: Zerbinatti, Celina V, et al.
Publicado: (2008)

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
por: Saito, Yuhki, et al.
Publicado: (2011)

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles
por: Groemer, Teja W., et al.
Publicado: (2011)

An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients
por: Poulsen, Ebbe T., et al.
Publicado: (2017)

β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes
por: Jakhria, Toral, et al.
Publicado: (2014)

LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor
por: de Laat, Rian, et al.
Publicado: (2015)

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development
por: Ramaker, Jenna M., et al.
Publicado: (2016)

Retraction: An aberrant phosphorylation of amyloid precursor protein tyrosine regulates its trafficking and the binding to the clathrin endocytic complex in neural stem cells of Alzheimer's disease patients
Publicado: (2023)

Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis
por: Annunziata, Ida, et al.
Publicado: (2013)

Pharmacological targeting of the β-amyloid precursor protein intracellular domain
por: Branca, Caterina, et al.
Publicado: (2014)

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles
por: Cone, Allaura S., et al.
Publicado: (2020)

Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know?
por: Lin, Tong, et al.
Publicado: (2021)

Multisite tyrosine phosphorylation of the N‐terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein
por: Dunning, Christopher J. R., et al.
Publicado: (2016)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Novel Adaptors of Amyloid Precursor Protein Intracellular Domain and Their Functional Implications
por: Chakrabarti, Arunabha, et al.
Publicado: (2012)

Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain
por: Lewis, Victoria, et al.
Publicado: (2012)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
por: Edgar, James R., et al.
Publicado: (2015)

Copper binding to the Alzheimer’s disease amyloid precursor protein
por: Kong, Geoffrey K.-W., et al.
Publicado: (2007)

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies
por: Hermey, Guido
Publicado: (2015)

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
por: Evrard, Caroline, et al.
Publicado: (2018)

Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2013)

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
Publicado: (1995)

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
por: Cam, Judy A, et al.
Publicado: (2006)

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production
por: Tan, Jing Zhi A., et al.
Publicado: (2020)

Biology and pathophysiology of the amyloid precursor protein
por: Zheng, Hui, et al.
Publicado: (2011)

Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View
por: Staudt, Catherine, et al.
Publicado: (2016)

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
por: Tamayev, Robert, et al.
Publicado: (2009)

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
por: Nizzari, Mario, et al.
Publicado: (2012)

FAD Mutations in Amyloid Precursor Protein Do Not Directly Perturb Intracellular Calcium Homeostasis
por: Stieren, Emily, et al.
Publicado: (2010)

Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model
por: Shen, Qi, et al.
Publicado: (2022)

Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing
por: Liu, Chia-Chen, et al.
Publicado: (2012)

Intracellular Trafficking of Guanylate-Binding Proteins Is Regulated by Heterodimerization in a Hierarchical Manner
por: Britzen-Laurent, Nathalie, et al.
Publicado: (2010)

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
por: Guix, Francesc X., et al.
Publicado: (2017)

Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein
por: Seki, Tsuneyoshi, et al.
Publicado: (2020)

Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis
por: Peng, Xi, et al.
Publicado: (2019)

The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?
por: Bórquez, Daniel A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cs9je5hie0f3duqhio9i4oc0ks