Cargando…

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-based vaccine that provides high-grade, durable protection against infection with Pf malaria. Several...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richie, Thomas L., Billingsley, Peter F., Sim, B. Kim Lee, James, Eric R., Chakravarty, Sumana, Epstein, Judith E., Lyke, Kirsten E., Mordmüller, Benjamin, Alonso, Pedro, Duffy, Patrick E., Doumbo, Ogobara K., Sauerwein, Robert W., Tanner, Marcel, Abdulla, Salim, Kremsner, Peter G., Seder, Robert A., Hoffman, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077156/ https://www.ncbi.nlm.nih.gov/pubmed/26469720 http://dx.doi.org/10.1016/j.vaccine.2015.09.096

Ejemplares similares

Progress with PfSPZ Vaccine, a radiation attenuated Plasmodium falciparum sporozoite vaccine
por: Billingsley, Peter, et al.
Publicado: (2014)

Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
por: KC, Natasha, et al.
Publicado: (2022)

Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa
por: Silva, Joana C., et al.
Publicado: (2022)

Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants
por: Jongo, Said A., et al.
Publicado: (2019)

A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection
por: Mordmüller, Benjamin, et al.
Publicado: (2022)

Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults
por: Jongo, Said A., et al.
Publicado: (2023)

Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
por: Sulyok, Zita, et al.
Publicado: (2021)

PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial
por: Coulibaly, Drissa, et al.
Publicado: (2022)

Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults
por: Jongo, Said A., et al.
Publicado: (2021)

Adaptive clinical trials of three PfSPZ products for development of a whole sporozoite vaccine that prevents Plasmodium falciparum infection, disease and transmission
por: Hoffman, Stephen L
Publicado: (2012)

Multi-Dose Priming Regimens of PfSPZ Vaccine: Safety and Efficacy against Controlled Human Malaria Infection in Equatoguinean Adults
por: Jongo, Said Abdallah, et al.
Publicado: (2022)

Advancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men
por: Olotu, Ally, et al.
Publicado: (2018)

PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection
por: Murphy, Sean C., et al.
Publicado: (2021)

Caregiver and community perceptions and experiences participating in an infant malaria prevention trial of PfSPZ Vaccine administered by direct venous inoculation: a qualitative study in Siaya County, western Kenya
por: Achieng, Florence, et al.
Publicado: (2020)

1241. PfSPZ Vaccine Administered by Direct Venous Inoculation to Prevent Plasmodium falciparum Malaria is as Safe as Normal Saline – a Meta-analysis of 12 Randomized Controlled Clinical Trials
por: Church, L W Preston
Publicado: (2020)

Controlled human malaria infections using aseptic, purified cryopreserved Plasmodium falciparum sporozoites administered by needle and syringe
por: Billingsley, Peter, et al.
Publicado: (2014)

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection
por: Scally, Stephen W., et al.
Publicado: (2018)

Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection
por: Lyke, Kirsten E., et al.
Publicado: (2015)

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites
por: Roestenberg, Meta, et al.
Publicado: (2013)

Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections
por: Billingsley, Peter F., et al.
Publicado: (2021)

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria
por: James, Eric R., et al.
Publicado: (2022)

Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites
por: Chakravarty, Sumana, et al.
Publicado: (2022)

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres
por: Mordmüller, Benjamin, et al.
Publicado: (2015)

Development of an attenuated sporozoite vaccine to prevent and eliminate Plasmodium falciparum malaria
por: Billingsley, Peter F
Publicado: (2010)

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood
por: Murphy, Sean C., et al.
Publicado: (2018)

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection
por: Zanghì, Gigliola, et al.
Publicado: (2018)

Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults
por: Jongo, Said A., et al.
Publicado: (2018)

Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens
por: Ibanez, Javier, et al.
Publicado: (2022)

Malaria sporozoite proteome leaves a trail
por: Vignali, Marissa, et al.
Publicado: (2009)

Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial
por: Lyke, Kirsten E., et al.
Publicado: (2010)

Spz/Toll-6 signal guides organotropic metastasis in Drosophila
por: Mishra-Gorur, Ketu, et al.
Publicado: (2019)

Novel approaches to whole sporozoite vaccination against malaria(✩)
por: Bijker, Else M., et al.
Publicado: (2015)

Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
por: Ventimiglia, Noah T., et al.
Publicado: (2021)

IMRAS—Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS
por: Sedegah, Martha, et al.
Publicado: (2021)

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites
por: Atre, Tanmaya, et al.
Publicado: (2019)

Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization
por: Nahrendorf, Wiebke, et al.
Publicado: (2015)

The road to Cybathlon 2016 - Functional electrical stimulation cycling Team IRPT/SPZ
por: Laubacher, Marco, et al.
Publicado: (2017)

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria
por: Bijker, Else M, et al.
Publicado: (2015)

Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium
por: Lyke, Kirsten E., et al.
Publicado: (2018)

Functional human IgA targets a conserved site on malaria sporozoites
por: Tan, Joshua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_al33935m8qt70k8qo6muepbrt3