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N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells

[Image: see text] N-Myristoyltransferase (NMT) covalently attaches a C14 fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We have recently shown that selective NMT inhibition leads to dose-responsive loss of N-myristoylation on more than 100 p...

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Detalles Bibliográficos
Autores principales:	Thinon, Emmanuelle, Morales-Sanfrutos, Julia, Mann, David J., Tate, Edward W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077176/ https://www.ncbi.nlm.nih.gov/pubmed/27267252 http://dx.doi.org/10.1021/acschembio.6b00371

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