Serum total IgG and IgG4 levels in thyroid eye disease

PURPOSE: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients wit...

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Detalles Bibliográficos
Autores principales: Sy, Aileen, Silkiss, Rona Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077241/
https://www.ncbi.nlm.nih.gov/pubmed/27799828
http://dx.doi.org/10.2147/IMCRJ.S116331
Descripción
Sumario:PURPOSE: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED. RESULTS: Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD without any additional systemic disease. Total IgG and IgG subclass levels were found to be an inadequate proxy for TSI elevation. CONCLUSION: There may be a subtype of TED patients with elevated IgG4 in the absence of IgG4-RD systemic findings.

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