Serum total IgG and IgG4 levels in thyroid eye disease

PURPOSE: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Sy, Aileen, Silkiss, Rona Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077241/
https://www.ncbi.nlm.nih.gov/pubmed/27799828
http://dx.doi.org/10.2147/IMCRJ.S116331
_version_ 1782462148253843456
author Sy, Aileen
Silkiss, Rona Z
author_facet Sy, Aileen
Silkiss, Rona Z
author_sort Sy, Aileen
collection PubMed
description PURPOSE: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED. RESULTS: Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD without any additional systemic disease. Total IgG and IgG subclass levels were found to be an inadequate proxy for TSI elevation. CONCLUSION: There may be a subtype of TED patients with elevated IgG4 in the absence of IgG4-RD systemic findings.
format Online
Article
Text
id pubmed-5077241
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-50772412016-10-31 Serum total IgG and IgG4 levels in thyroid eye disease Sy, Aileen Silkiss, Rona Z Int Med Case Rep J Case Series PURPOSE: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED. RESULTS: Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD without any additional systemic disease. Total IgG and IgG subclass levels were found to be an inadequate proxy for TSI elevation. CONCLUSION: There may be a subtype of TED patients with elevated IgG4 in the absence of IgG4-RD systemic findings. Dove Medical Press 2016-10-20 /pmc/articles/PMC5077241/ /pubmed/27799828 http://dx.doi.org/10.2147/IMCRJ.S116331 Text en © 2016 Sy and Silkiss. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Sy, Aileen
Silkiss, Rona Z
Serum total IgG and IgG4 levels in thyroid eye disease
title Serum total IgG and IgG4 levels in thyroid eye disease
title_full Serum total IgG and IgG4 levels in thyroid eye disease
title_fullStr Serum total IgG and IgG4 levels in thyroid eye disease
title_full_unstemmed Serum total IgG and IgG4 levels in thyroid eye disease
title_short Serum total IgG and IgG4 levels in thyroid eye disease
title_sort serum total igg and igg4 levels in thyroid eye disease
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077241/
https://www.ncbi.nlm.nih.gov/pubmed/27799828
http://dx.doi.org/10.2147/IMCRJ.S116331
work_keys_str_mv AT syaileen serumtotaliggandigg4levelsinthyroideyedisease
AT silkissronaz serumtotaliggandigg4levelsinthyroideyedisease

Ejemplares similares