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Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia
BACKGROUND: Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes. METHODS: Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077269/ https://www.ncbi.nlm.nih.gov/pubmed/27799733 http://dx.doi.org/10.2147/OPTH.S117803 |
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author | Schiavi, Costantino Tassi, Filippo Finzi, Alessandro Strobbe, Ernesto Cellini, Mauro |
author_facet | Schiavi, Costantino Tassi, Filippo Finzi, Alessandro Strobbe, Ernesto Cellini, Mauro |
author_sort | Schiavi, Costantino |
collection | PubMed |
description | BACKGROUND: Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes. METHODS: Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT. RESULTS: The amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0.0001) and the sound eye group (P=0.0001), but also between the latter two groups (P=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (P=0.0002), but also between the control group and the sound eye group (P=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (P=0.0001) or the sound eye group (P=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (P=0.0025) and sound (P=0.0023) eyes, but also in the healthy control group (P=0.0001). CONCLUSION: These data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease. |
format | Online Article Text |
id | pubmed-5077269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50772692016-10-31 Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia Schiavi, Costantino Tassi, Filippo Finzi, Alessandro Strobbe, Ernesto Cellini, Mauro Clin Ophthalmol Original Research BACKGROUND: Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes. METHODS: Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT. RESULTS: The amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0.0001) and the sound eye group (P=0.0001), but also between the latter two groups (P=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (P=0.0002), but also between the control group and the sound eye group (P=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (P=0.0001) or the sound eye group (P=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (P=0.0025) and sound (P=0.0023) eyes, but also in the healthy control group (P=0.0001). CONCLUSION: These data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease. Dove Medical Press 2016-10-19 /pmc/articles/PMC5077269/ /pubmed/27799733 http://dx.doi.org/10.2147/OPTH.S117803 Text en © 2016 Schiavi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Schiavi, Costantino Tassi, Filippo Finzi, Alessandro Strobbe, Ernesto Cellini, Mauro Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title | Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title_full | Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title_fullStr | Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title_full_unstemmed | Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title_short | Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
title_sort | steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077269/ https://www.ncbi.nlm.nih.gov/pubmed/27799733 http://dx.doi.org/10.2147/OPTH.S117803 |
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