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Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner
Telomerase was evaluated as a therapeutic oncotarget by studying the efficacy of the telomerase inhibitor imetelstat in non-small cell lung cancer (NSCLC) cell lines to determine the range of response phenotypes and identify potential biomarkers of response. A panel of 63 NSCLC cell lines was studie...
Autores principales: | Frink, Robin E., Peyton, Michael, Schiller, Joan H., Gazdar, Adi F., Shay, Jerry W., Minna, John D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077965/ https://www.ncbi.nlm.nih.gov/pubmed/27192120 http://dx.doi.org/10.18632/oncotarget.9335 |
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