Cargando…

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer

Biotransformation by the endophytes of certain plants changes various compounds, and this ‘green’ chemistry becomes increasingly important for finding new products with pharmacological activity. In this study, polyphyllin VII (PPL7) was biotransformed by endophytes from the medicinal plant Paris pol...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Dong-Xu, Li, Guo-Hong, Gu, Xiao-Ting, Zhang, Liang, Mao, Ai-Qin, Wei, Juan, Liu, De-Quan, Shi, Gui-Yang, Ma, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077978/ https://www.ncbi.nlm.nih.gov/pubmed/26701723 http://dx.doi.org/10.18632/oncotarget.6674

Ejemplares similares

Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation
por: Que, Zujun, et al.
Publicado: (2023)

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo
por: Zhang, Chao, et al.
Publicado: (2021)

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer
por: Song, Cheng, et al.
Publicado: (2021)

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
por: Ahmad, Bashir, et al.
Publicado: (2021)

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production
por: Zhou, Long, et al.
Publicado: (2020)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

Polyphyllin I Effects Candida albicans via Inhibition of Virulence Factors
por: Sun, Ai-Mei, et al.
Publicado: (2023)

Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice
por: Gu, Linhui, et al.
Publicado: (2016)

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Polyphyllin I Inhibits Propionibacterium acnes-Induced Inflammation In Vitro
por: Zhu, Tingting, et al.
Publicado: (2018)

Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer
por: Zhao, Liubiqi, et al.
Publicado: (2021)

Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer
por: Yu, Jinglu, et al.
Publicado: (2020)

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells
por: He, Hao, et al.
Publicado: (2020)

Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer
por: He, Dong-Xu, et al.
Publicado: (2016)

Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway
por: Jiao, Yuhan, et al.
Publicado: (2022)

Polyphyllin VII induces apoptosis and autophagy via mediating H(2)O(2) levels and the JNK pathway in human osteosarcoma U2OS cells
por: Li, Xiangde, et al.
Publicado: (2021)

Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy
por: Duanmu, J, et al.
Publicado: (2011)

The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats
por: Huang, Ruizhen, et al.
Publicado: (2020)

Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs
por: Niu, Weipin, et al.
Publicado: (2020)

Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla
por: Hua, Xin, et al.
Publicado: (2022)

Polyphyllin B Suppresses Gastric Tumor Growth by Modulating Iron Metabolism and Inducing Ferroptosis
por: Hu, Can, et al.
Publicado: (2023)

Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis
por: Feng, Feifei, et al.
Publicado: (2019)

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
por: Zheng, Fang, et al.
Publicado: (2023)

Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation
por: Han, Jun, et al.
Publicado: (2020)

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
por: Wang, Qiong, et al.
Publicado: (2018)

Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway
por: Xiao, Ting, et al.
Publicado: (2018)

Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma
por: Yang, Meng-Zhe, et al.
Publicado: (2021)

Production of Anti-Cancer Agent Using Microbial Biotransformation
por: Roh, Changhyun, et al.
Publicado: (2014)

Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
por: Zheng, Fang, et al.
Publicado: (2023)

Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy
por: Siripuram, Ram, et al.
Publicado: (2022)

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels
por: Li, Guo-Bing, et al.
Publicado: (2017)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway
por: Luo, Qihui, et al.
Publicado: (2022)

Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells
por: Zhao, YueYang, et al.
Publicado: (2019)

Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo
por: Chang, Junli, et al.
Publicado: (2017)

Synergistic Anticancer Effects of Polyphyllin I and Evodiamine on Freshly-Removed Human Gastric Tumors
por: Yue, Guofeng, et al.
Publicado: (2013)

Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells
por: Du, Haiyan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_67gtpvrn82bpr6j7hal4c0hh9e