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Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells

The antibody-dependent cellular cytotoxicity (ADCC) of natural killer (NK) cells is assumed to contribute to the clinical efficacy of monoclonal antibodies (mAbs) in chronic lymphocytic leukemia (CLL) and other hematopoietic malignancies of B cell origin. We sought to determine whether reactive oxyg...

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Detalles Bibliográficos
Autores principales:	Werlenius, Olle, Aurelius, Johan, Hallner, Alexander, Akhiani, Ali A., Simpanen, Maria, Martner, Anna, Andersson, Per-Ola, Hellstrand, Kristoffer, Thorén, Fredrik B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077995/ https://www.ncbi.nlm.nih.gov/pubmed/27097113 http://dx.doi.org/10.18632/oncotarget.8769

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