Cargando…
The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis
Although a number of studies suggested that WT1 rs16754 polymorphism might be related to decreased relapse free survival (RFS) and overall survival (OS). The results remain controversial. Published reports were searched in PubMed, EMBASE, and Google Scholar. Twelve publications with 3903 patients ha...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077998/ https://www.ncbi.nlm.nih.gov/pubmed/26992216 http://dx.doi.org/10.18632/oncotarget.8117 |
_version_ | 1782462285624639488 |
---|---|
author | Long, Jianting Fang, Shi Dai, Qiangsheng Liu, Xiaolian Zhu, Wanshou Wang, Shenming |
author_facet | Long, Jianting Fang, Shi Dai, Qiangsheng Liu, Xiaolian Zhu, Wanshou Wang, Shenming |
author_sort | Long, Jianting |
collection | PubMed |
description | Although a number of studies suggested that WT1 rs16754 polymorphism might be related to decreased relapse free survival (RFS) and overall survival (OS). The results remain controversial. Published reports were searched in PubMed, EMBASE, and Google Scholar. Twelve publications with 3903 patients had met the inclusion criteria and were subjected to further examination. We found WT1 rs16754 polymorphism was significantly associated with OS in AML (OR = 0.62; 95% CI 0.52 − 0.75; p < 0.00001; I(2) = 47%). WT1 rs16754 polymorphism was also significantly associated with RFS in AML (OR = 0.69; 95% CI 0.57 − 0.83; p < 0.001; I(2) = 46%). In the subgroup analyses of age, race, and subtype of AML, WT1 rs16754 polymorphism was a independent favorable-risk marker. In conclusion, WT1 rs16754 polymorphism is associated with better survival of AML. It could be used as a cost-effective prognostic biomarker for AML. |
format | Online Article Text |
id | pubmed-5077998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-50779982016-10-28 The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis Long, Jianting Fang, Shi Dai, Qiangsheng Liu, Xiaolian Zhu, Wanshou Wang, Shenming Oncotarget Research Paper Although a number of studies suggested that WT1 rs16754 polymorphism might be related to decreased relapse free survival (RFS) and overall survival (OS). The results remain controversial. Published reports were searched in PubMed, EMBASE, and Google Scholar. Twelve publications with 3903 patients had met the inclusion criteria and were subjected to further examination. We found WT1 rs16754 polymorphism was significantly associated with OS in AML (OR = 0.62; 95% CI 0.52 − 0.75; p < 0.00001; I(2) = 47%). WT1 rs16754 polymorphism was also significantly associated with RFS in AML (OR = 0.69; 95% CI 0.57 − 0.83; p < 0.001; I(2) = 46%). In the subgroup analyses of age, race, and subtype of AML, WT1 rs16754 polymorphism was a independent favorable-risk marker. In conclusion, WT1 rs16754 polymorphism is associated with better survival of AML. It could be used as a cost-effective prognostic biomarker for AML. Impact Journals LLC 2016-03-16 /pmc/articles/PMC5077998/ /pubmed/26992216 http://dx.doi.org/10.18632/oncotarget.8117 Text en Copyright: © 2016 Long et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Long, Jianting Fang, Shi Dai, Qiangsheng Liu, Xiaolian Zhu, Wanshou Wang, Shenming The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title | The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title_full | The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title_fullStr | The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title_full_unstemmed | The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title_short | The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis |
title_sort | wilms tumor-1 (wt1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (aml): a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077998/ https://www.ncbi.nlm.nih.gov/pubmed/26992216 http://dx.doi.org/10.18632/oncotarget.8117 |
work_keys_str_mv | AT longjianting thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT fangshi thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT daiqiangsheng thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT liuxiaolian thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT zhuwanshou thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT wangshenming thewilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT longjianting wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT fangshi wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT daiqiangsheng wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT liuxiaolian wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT zhuwanshou wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis AT wangshenming wilmstumor1wt1rs16754polymorphismisaprognosticfactorinacutemyeloidleukemiaamlametaanalysis |