GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases

Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABR(A3) is reportedly upregulated in lung cancer. Herein, we show that high GABR(A3) protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasi...

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Detalles Bibliográficos
Autores principales: Liu, Liping, Yang, Chenglin, Shen, Jianfei, Huang, Liyan, Lin, Weixuan, Tang, Hailing, Liang, Wenhua, Shao, Wenlong, Zhang, Haibo, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078017/
https://www.ncbi.nlm.nih.gov/pubmed/27081042
http://dx.doi.org/10.18632/oncotarget.8700
Descripción
Sumario:Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABR(A3) is reportedly upregulated in lung cancer. Herein, we show that high GABR(A3) protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABR(A3) induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma both in vitro and in vivo. These results indicate that GABR(A3) promotes lymph node metastasis and may thus be an effective therapeutic target for anticancer treatment.

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