GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases

Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABR(A3) is reportedly upregulated in lung cancer. Herein, we show that high GABR(A3) protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasi...

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Autores principales: Liu, Liping, Yang, Chenglin, Shen, Jianfei, Huang, Liyan, Lin, Weixuan, Tang, Hailing, Liang, Wenhua, Shao, Wenlong, Zhang, Haibo, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078017/
https://www.ncbi.nlm.nih.gov/pubmed/27081042
http://dx.doi.org/10.18632/oncotarget.8700
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author Liu, Liping
Yang, Chenglin
Shen, Jianfei
Huang, Liyan
Lin, Weixuan
Tang, Hailing
Liang, Wenhua
Shao, Wenlong
Zhang, Haibo
He, Jianxing
author_facet Liu, Liping
Yang, Chenglin
Shen, Jianfei
Huang, Liyan
Lin, Weixuan
Tang, Hailing
Liang, Wenhua
Shao, Wenlong
Zhang, Haibo
He, Jianxing
author_sort Liu, Liping
collection PubMed
description Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABR(A3) is reportedly upregulated in lung cancer. Herein, we show that high GABR(A3) protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABR(A3) induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma both in vitro and in vivo. These results indicate that GABR(A3) promotes lymph node metastasis and may thus be an effective therapeutic target for anticancer treatment.
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spelling pubmed-50780172016-10-28 GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases Liu, Liping Yang, Chenglin Shen, Jianfei Huang, Liyan Lin, Weixuan Tang, Hailing Liang, Wenhua Shao, Wenlong Zhang, Haibo He, Jianxing Oncotarget Research Paper Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABR(A3) is reportedly upregulated in lung cancer. Herein, we show that high GABR(A3) protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABR(A3) induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma both in vitro and in vivo. These results indicate that GABR(A3) promotes lymph node metastasis and may thus be an effective therapeutic target for anticancer treatment. Impact Journals LLC 2016-04-11 /pmc/articles/PMC5078017/ /pubmed/27081042 http://dx.doi.org/10.18632/oncotarget.8700 Text en Copyright: © 2016 Liu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Liping
Yang, Chenglin
Shen, Jianfei
Huang, Liyan
Lin, Weixuan
Tang, Hailing
Liang, Wenhua
Shao, Wenlong
Zhang, Haibo
He, Jianxing
GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title_full GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title_fullStr GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title_full_unstemmed GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title_short GABR(A3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
title_sort gabr(a3) promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078017/
https://www.ncbi.nlm.nih.gov/pubmed/27081042
http://dx.doi.org/10.18632/oncotarget.8700
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