Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells

We investigated whether platelets prime colon cancer cells for metastasis and whether pharmacological inhibition of platelet function may prevent it. Coculturing HT29 human colon carcinoma cells with human platelets led to the induction of mesenchymal-like cancer cells characterized by downregulatio...

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Detalles Bibliográficos
Autores principales: Guillem-Llobat, Paloma, Dovizio, Melania, Bruno, Annalisa, Ricciotti, Emanuela, Cufino, Valerio, Sacco, Angela, Grande, Rosalia, Alberti, Sara, Arena, Vincenzo, Cirillo, Mariangela, Patrono, Carlo, FitzGerald, Garret A., Steinhilber, Dieter, Sgambato, Alessandro, Patrignani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078026/
https://www.ncbi.nlm.nih.gov/pubmed/27074574
http://dx.doi.org/10.18632/oncotarget.8655

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