Cargando…

MERTK as a novel therapeutic target in head and neck cancer

Although head and neck cancer (HNSCC) is the sixth most common tumor entity worldwide therapy options remain limited leading to 5-year survival rates of only 50 %. MERTK is a promising therapeutic target in several tumor entities, however, its role in HNSCC has not been described yet. The aim of our...

Descripción completa

Detalles Bibliográficos
Autores principales:	von Mässenhausen, Anne, Sanders, Christine, Thewes, Britta, Deng, Mario, Queisser, Angela, Vogel, Wenzel, Kristiansen, Glen, Duensing, Stefan, Schröck, Andreas, Bootz, Friedrich, Brossart, Peter, Kirfel, Jutta, Heasley, Lynn, Brägelmann, Johannes, Perner, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078043/ https://www.ncbi.nlm.nih.gov/pubmed/27081701 http://dx.doi.org/10.18632/oncotarget.8724

Ejemplares similares

Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression
por: von Mässenhausen, Anne, et al.
Publicado: (2016)

PD-L1: a novel prognostic biomarker in head and neck squamous cell carcinoma
por: Müller, Tim, et al.
Publicado: (2017)

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types
por: Syring, Isabella, et al.
Publicado: (2016)

PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas
por: Franzen, Alina, et al.
Publicado: (2017)

MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy
por: Laban, Simon, et al.
Publicado: (2017)

PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma
por: Sailer, Verena, et al.
Publicado: (2016)

PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma
por: Sailer, Verena, et al.
Publicado: (2017)

Comparison of quantification algorithms for circulating cell-free DNA methylation biomarkers in blood plasma from cancer patients
por: de Vos, Luka, et al.
Publicado: (2017)

Nectin-4 is widely expressed in head and neck squamous cell carcinoma
por: Sanders, Christine, et al.
Publicado: (2022)

Sex Determining Region Y-Box 2 (SOX2) Amplification Is an Independent Indicator of Disease Recurrence in Sinonasal Cancer
por: Schröck, Andreas, et al.
Publicado: (2013)

Clinical performance validation of PITX2 DNA methylation as prognostic biomarker in patients with head and neck squamous cell carcinoma
por: Sailer, Verena, et al.
Publicado: (2017)

Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT
por: Lemster, Anna-Lena, et al.
Publicado: (2022)

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling
por: Offermann, Anne, et al.
Publicado: (2016)

EVI1 as a Marker for Lymph Node Metastasis in HNSCC
por: Idel, Christian, et al.
Publicado: (2020)

Mediator Complex Subunit MED1 Protein Expression Is Decreased during Bladder Cancer Progression
por: Klümper, Niklas, et al.
Publicado: (2017)

MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines
por: Kim, Jung Eun, et al.
Publicado: (2017)

CTLA4 promoter methylation predicts response and progression-free survival in stage IV melanoma treated with anti-CTLA-4 immunotherapy (ipilimumab)
por: Fietz, Simon, et al.
Publicado: (2020)

PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients
por: Goltz, Diane, et al.
Publicado: (2017)

Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma
por: Holderried, Tobias A. W., et al.
Publicado: (2019)

Web-TCGA: an online platform for integrated analysis of molecular cancer data sets
por: Deng, Mario, et al.
Publicado: (2016)

Normics: Proteomic Normalization by Variance and Data-Inherent Correlation Structure
por: Dressler, Franz F., et al.
Publicado: (2022)

Spatial Distribution of Immune Cells in Head and Neck Squamous Cell Carcinomas
por: Idel, Christian, et al.
Publicado: (2021)

Harnessing MerTK agonism for targeted therapeutics
por: Kedage, Vivekananda, et al.
Publicado: (2019)

Regulation of bone homeostasis by MERTK and TYRO3
por: Engelmann, Janik, et al.
Publicado: (2022)

Long Term Remission and Cardiac Toxicity of a Combination of Ipilimumab and Nivolumab in a Patient With Metastatic Head and Neck Carcinoma After Progression Following Nivolumab Monotherapy
por: Schwab, Katjana S., et al.
Publicado: (2019)

FirebrowseR: an R client to the Broad Institute’s Firehose Pipeline
por: Deng, Mario, et al.
Publicado: (2017)

Prognostic Value of the New Prostate Cancer International Society of Urological Pathology Grade Groups
por: Offermann, Anne, et al.
Publicado: (2017)

Tyro3 Modulates Mertk-Associated Retinal Degeneration
por: Vollrath, Douglas, et al.
Publicado: (2015)

The role of endothelial MERTK during the inflammatory response in lungs
por: Li, Yitong, et al.
Publicado: (2019)

MerTK, a risk factor for NASH fibrosis
por: Wang, Xiaobo, et al.
Publicado: (2020)

Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors
por: Klümper, Niklas, et al.
Publicado: (2015)

MerTK is required for apoptotic cell–induced T cell tolerance
por: Wallet, Mark A., et al.
Publicado: (2008)

MerTK is a novel therapeutic target in gastric cancer
por: Yi, Jun Ho, et al.
Publicado: (2015)

The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
por: Wang, Li, et al.
Publicado: (2022)

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
por: Nguyen, Linda T., et al.
Publicado: (2023)

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment
por: Nettersheim, Daniel, et al.
Publicado: (2016)

Expression of Prostate-Specific Membrane Antigen (PSMA) on Biopsies Is an Independent Risk Stratifier of Prostate Cancer Patients at Time of Initial Diagnosis
por: Hupe, Marie Christine, et al.
Publicado: (2018)

ERG is specifically associated with ETS-2 and ETV-4, but not with ETS-1, in prostate cancer
por: ADLER, DAVID, et al.
Publicado: (2012)

Systematic evaluation and optimization of protein extraction parameters in diagnostic FFPE specimens
por: Dressler, Franz F., et al.
Publicado: (2022)

Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab
por: Schwab, Katjana S., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_negr5dugb6u68ev62rr8ihpack