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HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer

The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cance...

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Autores principales: He, Junyi, Shen, Sheng, Lu, Weiqi, Zhou, Yuhong, Hou, Yingyong, Zhang, Yong, Jiang, Ying, Liu, Houbao, Shao, Yebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078048/
https://www.ncbi.nlm.nih.gov/pubmed/27092878
http://dx.doi.org/10.18632/oncotarget.8740
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author He, Junyi
Shen, Sheng
Lu, Weiqi
Zhou, Yuhong
Hou, Yingyong
Zhang, Yong
Jiang, Ying
Liu, Houbao
Shao, Yebo
author_facet He, Junyi
Shen, Sheng
Lu, Weiqi
Zhou, Yuhong
Hou, Yingyong
Zhang, Yong
Jiang, Ying
Liu, Houbao
Shao, Yebo
author_sort He, Junyi
collection PubMed
description The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cancer is still unknown. Here, we reported that HDAC1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with GBC. Knockdown of HDAC1 using lentivirus delivery of HDAC1-specific shRNA abrogated the migration and invasion of GBC cells in vitro. TCF-12, as the HDAC1 binding protein, has also correlates with poor prognosis in GBC patients. And there is a positive correlation between HDAC1 and TCF-12 which leading the high invasion and migration ability of GBC cells. Taken together, our data suggested that HDAC1 and TCF-12 are a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in GBC.
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spelling pubmed-50780482016-10-28 HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer He, Junyi Shen, Sheng Lu, Weiqi Zhou, Yuhong Hou, Yingyong Zhang, Yong Jiang, Ying Liu, Houbao Shao, Yebo Oncotarget Research Paper The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cancer is still unknown. Here, we reported that HDAC1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with GBC. Knockdown of HDAC1 using lentivirus delivery of HDAC1-specific shRNA abrogated the migration and invasion of GBC cells in vitro. TCF-12, as the HDAC1 binding protein, has also correlates with poor prognosis in GBC patients. And there is a positive correlation between HDAC1 and TCF-12 which leading the high invasion and migration ability of GBC cells. Taken together, our data suggested that HDAC1 and TCF-12 are a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in GBC. Impact Journals LLC 2016-04-15 /pmc/articles/PMC5078048/ /pubmed/27092878 http://dx.doi.org/10.18632/oncotarget.8740 Text en Copyright: © 2016 He et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
He, Junyi
Shen, Sheng
Lu, Weiqi
Zhou, Yuhong
Hou, Yingyong
Zhang, Yong
Jiang, Ying
Liu, Houbao
Shao, Yebo
HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title_full HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title_fullStr HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title_full_unstemmed HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title_short HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
title_sort hdac1 promoted migration and invasion binding with tcf12 by promoting emt progress in gallbladder cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078048/
https://www.ncbi.nlm.nih.gov/pubmed/27092878
http://dx.doi.org/10.18632/oncotarget.8740
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