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Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium

High-grade serous carcinoma (HGSC) is the most common and lethal form of ovarian cancer. PAX8 is a transcription factor expressed in fallopian tube epithelial cells and in 80–96% of HGSC tumors. The ovarian surface epithelium (OSE) only acquires PAX8 expression after malignant transformation. In thi...

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Detalles Bibliográficos
Autores principales:	Rodgers, Laura H., hAinmhire, Eoghainín Ó, Young, Alexandria N., Burdette, Joanna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078051/ https://www.ncbi.nlm.nih.gov/pubmed/27129161 http://dx.doi.org/10.18632/oncotarget.9051

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