Cargando…

MUC1 stimulates EGFR expression and function in endometrial cancer

The current standard of care for endometrial cancer patients involves hysterectomy with adjuvant radiation and chemotherapy, with no effective treatment for advanced and metastatic disease. MUC1 is a large, heavily glycosylated transmembrane protein that lubricates and protects cell surfaces and inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Engel, Brian J., Bowser, Jessica L., Broaddus, Russell R., Carson, Daniel D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078052/ https://www.ncbi.nlm.nih.gov/pubmed/27092881 http://dx.doi.org/10.18632/oncotarget.8743

Ejemplares similares

Loss of polarity alters proliferation and differentiation in low-grade endometrial cancers by disrupting Notch signaling
por: Williams, Erin, et al.
Publicado: (2017)

Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB
por: Morgado, Micaela, et al.
Publicado: (2016)

Differential expression of MUC genes in endometrial and cervical tissues and tumors
por: Hebbar, Vidya, et al.
Publicado: (2005)

Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface
por: Francis, Lewis W., et al.
Publicado: (2021)

Mechanisms of mutant β-catenin in endometrial cancer progression
por: Parrish, Molly L., et al.
Publicado: (2022)

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance
por: Betge, Johannes, et al.
Publicado: (2016)

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells
por: Piyush, Tushar, et al.
Publicado: (2017)

The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation
por: Danysh, Brian P., et al.
Publicado: (2012)

Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma
por: Kim, Su-Mi, et al.
Publicado: (2012)

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
por: Li, Guangchao, et al.
Publicado: (2014)

Dendritic cells enhance the activity of human MUC1-stimulated mononuclear cells against breast cancer
por: Wang, Zhenyao, et al.
Publicado: (2013)

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro
por: Chorley, Brian N, et al.
Publicado: (2006)

Lewis(y) antigen promotes the progression of epithelial ovarian cancer by stimulating MUC1 expression
por: Hou, Rui, et al.
Publicado: (2017)

HE4 Transcription- and Splice Variants-Specific Expression in Endometrial Cancer and Correlation with Patient Survival
por: Jiang, Shi-Wen, et al.
Publicado: (2013)

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer
por: Yokoyama, Seiya, et al.
Publicado: (2017)

MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer
por: Luo, Yuan, et al.
Publicado: (2021)

MUC1-ARF—A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA
por: Chalick, Michael, et al.
Publicado: (2016)

MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner
por: Jin, Wei, et al.
Publicado: (2017)

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)
por: Hanson, Ryan L., et al.
Publicado: (2016)

Associations between the Expression of Mucins (MUC1, MUC2, MUC5AC, and MUC6) and Clinicopathologic Parameters of Human Breast Ductal Carcinomas
por: Do, Sung-Im, et al.
Publicado: (2013)

MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERα) in regulation of the MUC1 gene expression
por: Zaretsky, Joseph Z, et al.
Publicado: (2006)

Altered Expression of Transmembrane Mucins, MUC1 and MUC4, in Bladder Cancer: Pathological Implications in Diagnosis
por: Kaur, Sukhwinder, et al.
Publicado: (2014)

Immunohistochemical evidence of Muc1 expression during rat embryonic development
por: Lacunza, E., et al.
Publicado: (2010)

S100A4 Mediates Endometrial Cancer Invasion and is a Target of TGF-β1 Signaling
por: Xie, Ran, et al.
Publicado: (2009)

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis
por: Yamamoto-Furusho, Jesús K., et al.
Publicado: (2015)

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression
por: Jiang, Tao, et al.
Publicado: (2022)

Comparison of the Transmembrane Mucins MUC1 and MUC16 in Epithelial Barrier Function
por: Gipson, Ilene K., et al.
Publicado: (2014)

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas
por: Yokoyama, Seiya, et al.
Publicado: (2016)

Relationship between PTEN, DNA Mismatch Repair, and Tumor Histotype in Endometrial Carcinoma: Retained Positive Expression of PTEN Preferentially Identifies Sporadic Non-Endometrioid Carcinomas
por: Djordjevic, Bojana, et al.
Publicado: (2013)

MUC1: A multifunctional cell surface component of reproductive tissue epithelia
por: Brayman, Melissa, et al.
Publicado: (2004)

Amplification of MUC1 in prostate cancer metastasis and CRPC development
por: Wong, Nicholas, et al.
Publicado: (2016)

The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer
por: Duncan, Timothy J, et al.
Publicado: (2007)

Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS)
por: Buyuk, Melek, et al.
Publicado: (2023)

An immune competent orthotopic model of endometrial cancer with metastasis
por: Fedorko, Alyssa M., et al.
Publicado: (2020)

Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas – Implications for the progression of EGFR-mutated lung adenocarcinomas
por: Matsumura, Mai, et al.
Publicado: (2019)

MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer
por: Wu, Yuliang, et al.
Publicado: (2023)

MUC1-C activates EZH2 expression and function in human cancer cells
por: Rajabi, Hasan, et al.
Publicado: (2017)

Expression of MUC1, MUC2 and MUC5AC in salivary gland mucoepidermoid carcinoma: A case series with diagnostic implications
por: Sood, Neelam, et al.
Publicado: (2022)

Alterations in Mucin Expression in Ovarian Mucinous Tumors: Immunohistochemical Analysis of MUC2, MUC5AC, MUC6, and CD10 Expression
por: Hirabayashi, Kenichi, et al.
Publicado: (2008)

MUC1 and MUC5AC implication in Tunisian colorectal cancer patients
por: HAZGUI, Meriam, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_to98hpkushqmi0il362sohd47g