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Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer
PKCε is a transforming oncogene and a predictive biomarker of various human cancers. However, a precise in vivo link of PKCε to cancer induction, progression and metastasis remain undefined. To achieve these goals, we generated tissue specific conditional PKCε knockout mice (PKCε-CKO) using cre-lox...
Autores principales: | Hafeez, Bilal Bin, Meske, Louise, Singh, Ashok, Singh, Anupama, Zhong, Weixiong, Powers, Patricia, John, Manorama, Griep, Anne E., Verma, Ajit K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078076/ https://www.ncbi.nlm.nih.gov/pubmed/27102301 http://dx.doi.org/10.18632/oncotarget.8850 |
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