Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells

Programmed death-1 (PD-1) /programmed death-ligand 1 (PD-L1) engagement usually leads to diminished antitumor T-cell responses, which mediates the immune escape of tumor cells. However, little is known whether PD-1/PD-L1 could directly activates intracellular oncogenic signaling pathways in tumor ce...

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Detalles Bibliográficos
Autores principales: Dong, Ling, Lv, Huijuan, Li, Wei, Song, Zheng, Li, Lanfang, Zhou, Shiyong, Qiu, Lihua, Qian, Zhengzi, Liu, Xianming, Feng, Lixia, Meng, Bin, Fu, Kai, Wang, Xi, Pan-Hammarström, Qiang, Wang, Ping, Wang, Xianhuo, Zhang, Huilai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078100/
https://www.ncbi.nlm.nih.gov/pubmed/27147575
http://dx.doi.org/10.18632/oncotarget.9061

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