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Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development
The insulin-like growth factor (IGF) pathway is a key signal transduction pathway involved in cell proliferation, migration, and apoptosis. In dairy cows, IGF family proteins and binding receptors, including their intracellular binding partners, regulate mammary gland development. IGFs and IGF recep...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Developmental Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078143/ https://www.ncbi.nlm.nih.gov/pubmed/27795999 http://dx.doi.org/10.12717/DR.2016.20.3.179 |
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author | Ha, Woo Tae Jeong, Ha Yeon Lee, Seung Yoon Song, Hyuk |
author_facet | Ha, Woo Tae Jeong, Ha Yeon Lee, Seung Yoon Song, Hyuk |
author_sort | Ha, Woo Tae |
collection | PubMed |
description | The insulin-like growth factor (IGF) pathway is a key signal transduction pathway involved in cell proliferation, migration, and apoptosis. In dairy cows, IGF family proteins and binding receptors, including their intracellular binding partners, regulate mammary gland development. IGFs and IGF receptor interactions in mammary glands influence the early stages of mammogenesis, i.e., mammary ductal genesis until puberty. The IGF pathway includes three major components, IGFs (such as IGF-I, IGF-II, and insulin), their specific receptors, and their high-affinity binding partners (IGF binding proteins [IGFBPs]; i.e., IGFBP1–6), including specific proteases for each IGFBP. Additionally, IGFs and IGFBP interactions are critical for the bioactivities of various intracellular mechanisms, including cell proliferation, migration, and apoptosis. Notably, the interactions between IGFs and IGFBPs in the IGF pathway have been difficult to characterize during specific stages of bovine mammary gland development. In this review, we aim to describe the role of the interaction between IGFs and IGFBPs in overall mammary gland development in dairy cows. |
format | Online Article Text |
id | pubmed-5078143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Society of Developmental Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-50781432016-10-28 Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development Ha, Woo Tae Jeong, Ha Yeon Lee, Seung Yoon Song, Hyuk Dev Reprod Review Article The insulin-like growth factor (IGF) pathway is a key signal transduction pathway involved in cell proliferation, migration, and apoptosis. In dairy cows, IGF family proteins and binding receptors, including their intracellular binding partners, regulate mammary gland development. IGFs and IGF receptor interactions in mammary glands influence the early stages of mammogenesis, i.e., mammary ductal genesis until puberty. The IGF pathway includes three major components, IGFs (such as IGF-I, IGF-II, and insulin), their specific receptors, and their high-affinity binding partners (IGF binding proteins [IGFBPs]; i.e., IGFBP1–6), including specific proteases for each IGFBP. Additionally, IGFs and IGFBP interactions are critical for the bioactivities of various intracellular mechanisms, including cell proliferation, migration, and apoptosis. Notably, the interactions between IGFs and IGFBPs in the IGF pathway have been difficult to characterize during specific stages of bovine mammary gland development. In this review, we aim to describe the role of the interaction between IGFs and IGFBPs in overall mammary gland development in dairy cows. Korean Society of Developmental Biology 2016-09 /pmc/articles/PMC5078143/ /pubmed/27795999 http://dx.doi.org/10.12717/DR.2016.20.3.179 Text en © Journal of the Korean Society of Developmental Biology. All Rights Reserved http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ha, Woo Tae Jeong, Ha Yeon Lee, Seung Yoon Song, Hyuk Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title | Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title_full | Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title_fullStr | Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title_full_unstemmed | Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title_short | Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development |
title_sort | effects of the insulin-like growth factor pathway on the regulation of mammary gland development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078143/ https://www.ncbi.nlm.nih.gov/pubmed/27795999 http://dx.doi.org/10.12717/DR.2016.20.3.179 |
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