Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features

Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in t...

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Detalles Bibliográficos
Autores principales: García-González, Paulina A., Schinnerling, Katina, Sepúlveda-Gutiérrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Bárbara, Molina, María Carmen, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Óscar, Catalán, Diego Francisco, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A., Aguillón, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078319/
https://www.ncbi.nlm.nih.gov/pubmed/27826300
http://dx.doi.org/10.3389/fimmu.2016.00458

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