Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System

Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for nonco...

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Autores principales: Carrick, William T., Burks, Brandi, Cairns, Murray J., Kocerha, Jannet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078498/
https://www.ncbi.nlm.nih.gov/pubmed/27826551
http://dx.doi.org/10.3389/fmolb.2016.00069
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author Carrick, William T.
Burks, Brandi
Cairns, Murray J.
Kocerha, Jannet
author_facet Carrick, William T.
Burks, Brandi
Cairns, Murray J.
Kocerha, Jannet
author_sort Carrick, William T.
collection PubMed
description Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.
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spelling pubmed-50784982016-11-08 Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System Carrick, William T. Burks, Brandi Cairns, Murray J. Kocerha, Jannet Front Mol Biosci Molecular Biosciences Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease. Frontiers Media S.A. 2016-10-25 /pmc/articles/PMC5078498/ /pubmed/27826551 http://dx.doi.org/10.3389/fmolb.2016.00069 Text en Copyright © 2016 Carrick, Burks, Cairns and Kocerha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Carrick, William T.
Burks, Brandi
Cairns, Murray J.
Kocerha, Jannet
Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title_full Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title_fullStr Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title_full_unstemmed Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title_short Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System
title_sort noncoding rna regulation of dopamine signaling in diseases of the central nervous system
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078498/
https://www.ncbi.nlm.nih.gov/pubmed/27826551
http://dx.doi.org/10.3389/fmolb.2016.00069
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