PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer

Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptiona...

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Detalles Bibliográficos
Autores principales: Lopez-Campistrous, Ana, Adewuyi, Esther Ekpe, Benesch, Matthew G.K., Ko, Yi Man, Lai, Raymond, Thiesen, Aducio, Dewald, Jay, Wang, Peng, Chu, Karen, Ghosh, Sunita, Williams, David C., Vos, Larissa J., Brindley, David N., McMullen, Todd P.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078607/
https://www.ncbi.nlm.nih.gov/pubmed/27682510
http://dx.doi.org/10.1016/j.ebiom.2016.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078607/
https://www.ncbi.nlm.nih.gov/pubmed/27682510
http://dx.doi.org/10.1016/j.ebiom.2016.09.007

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