Cargando…

PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer

Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptiona...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopez-Campistrous, Ana, Adewuyi, Esther Ekpe, Benesch, Matthew G.K., Ko, Yi Man, Lai, Raymond, Thiesen, Aducio, Dewald, Jay, Wang, Peng, Chu, Karen, Ghosh, Sunita, Williams, David C., Vos, Larissa J., Brindley, David N., McMullen, Todd P.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078607/ https://www.ncbi.nlm.nih.gov/pubmed/27682510 http://dx.doi.org/10.1016/j.ebiom.2016.09.007

Ejemplares similares

Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition
por: Ekpe-Adewuyi, Esther, et al.
Publicado: (2016)

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation
por: Benesch, Matthew G.K., et al.
Publicado: (2018)

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling
por: Yang, Zelei, et al.
Publicado: (2021)

Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3
por: Tang, Xiaoyun, et al.
Publicado: (2019)

Follicular variant papillary thyroid carcinoma with a twist
por: Nwaeze, Obinna, et al.
Publicado: (2015)

RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1
por: Volodko, Natalia, et al.
Publicado: (2016)

Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo
por: Benesch, Matthew G.K., et al.
Publicado: (2016)

FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival
por: Elian, Fahed A, et al.
Publicado: (2021)

Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis
por: Meng, Guanmin, et al.
Publicado: (2020)

Single-operator cholangioscopy for diagnosis of cholangioadenoma (bile duct adenoma) and its potential impact on surgical management
por: Eccles, John, et al.
Publicado: (2018)

Human Cytomegalovirus Seropositivity and Viral DNA in Breast Tumors Are Associated with Poor Patient Prognosis
por: Yang, Zelei, et al.
Publicado: (2022)

SWATH-MS identification of CXCL7, LBP, TGFβ1 and PDGFRβ as novel biomarkers in human systemic mastocytosis
por: Graham, R. L. J., et al.
Publicado: (2022)

Lipid phosphate phosphatase-2 promotes tumor growth through increased c-Myc expression
por: Tang, Xiaoyun, et al.
Publicado: (2022)

Inflammatory Bowel Disease: A Gastrointestinal Presentation of Congenital Plasminogen Deficiency
por: Balram, Bhairavi, et al.
Publicado: (2021)

Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion
por: Nostedt, Jordan J., et al.
Publicado: (2019)

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis
por: Buhl, Eva M, et al.
Publicado: (2020)

Proteomic profiling of follicular and papillary thyroid tumors
por: Sofiadis, Anastasios, et al.
Publicado: (2012)

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells
por: Wu, Erxi, et al.
Publicado: (2008)

cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation
por: Albert, Eric, et al.
Publicado: (2010)

Primary Esophageal Tuberculosis Without Dysphagia or Odynophagia in a Patient Without HIV
por: Ogbomo, Henry, et al.
Publicado: (2020)

Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
por: Chuang, Hao-Wen, et al.
Publicado: (2021)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study
por: Yoon, Jung Hyun, et al.
Publicado: (2014)

Parental cancer and risk of papillary and follicular thyroid carcinoma.
por: Galanti, M. R., et al.
Publicado: (1997)

Mouse Models of Follicular and Papillary Thyroid Cancer Progression
por: Russo, Marika A., et al.
Publicado: (2012)

Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
por: Daniels, Gilbert H.
Publicado: (2016)

Rare behavior of follicular variant of papillary thyroid cancer
por: Helmi, Hadeel, et al.
Publicado: (2017)

Surgical management for follicular variant of papillary thyroid carcinoma
por: Tang, Jianing, et al.
Publicado: (2017)

PDGFR‐β and kidney fibrosis
por: Ortiz, Alberto
Publicado: (2020)

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
por: Chi, Sum Shing, et al.
Publicado: (2010)

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023)

Heterotopic Pancreas within the Proximal Hepatic Duct, Containing Intraductal Papillary Mucinous Neoplasm
por: Lawrence, Alistair J., et al.
Publicado: (2015)

Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance
por: Bekele, Raie T., et al.
Publicado: (2016)

Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid
por: Schulten, Hans-Juergen, et al.
Publicado: (2015)

Concurrent Papillary and Follicular Thyroid Cancer Presenting as Shoulder Pain
por: Santiago Carrion, Ada Marie, et al.
Publicado: (2021)

The Role of Claudin-1 Expression in Follicular and Papillary Thyroid Neoplasm
por: Miskad, Upik Anderiani, et al.
Publicado: (2022)

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae
por: Benesch, Matthew G. K., et al.
Publicado: (2020)

Is PDGFR an important target for E-3810?
por: Damia, Giovanna, et al.
Publicado: (2012)

Genomics of PDGFR-rearranged hypereosinophilic syndrome
por: Rheinbay, Esther, et al.
Publicado: (2023)

Research and surgical residency: moving beyond one-and-done projects and motivating for scholarly excellence
por: Benesch, Matthew G.K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ps3qbm2mrl8a3g18mhug4u5a24