Cargando…
Therapeutic Potential of Curcumin for the Treatment of Brain Tumors
Brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation. As new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemothe...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078657/ https://www.ncbi.nlm.nih.gov/pubmed/27807473 http://dx.doi.org/10.1155/2016/9324085 |
_version_ | 1782462425495240704 |
---|---|
author | Klinger, Neil V. Mittal, Sandeep |
author_facet | Klinger, Neil V. Mittal, Sandeep |
author_sort | Klinger, Neil V. |
collection | PubMed |
description | Brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation. As new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemotherapeutic benefits and low toxicity profile. Curcumin, found in the rhizome of turmeric, has extensive therapeutic promise via its antioxidant, anti-inflammatory, and antiproliferative properties. Preclinical in vitro and in vivo data have shown it to be an effective treatment for brain tumors including glioblastoma multiforme. These effects are potentiated by curcumin's ability to induce G2/M cell cycle arrest, activation of apoptotic pathways, induction of autophagy, disruption of molecular signaling, inhibition of invasion, and metastasis and by increasing the efficacy of existing chemotherapeutics. Further, clinical data suggest that it has low toxicity in humans even at large doses. Curcumin is a promising nutraceutical compound that should be evaluated in clinical trials for the treatment of human brain tumors. |
format | Online Article Text |
id | pubmed-5078657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50786572016-11-02 Therapeutic Potential of Curcumin for the Treatment of Brain Tumors Klinger, Neil V. Mittal, Sandeep Oxid Med Cell Longev Review Article Brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation. As new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemotherapeutic benefits and low toxicity profile. Curcumin, found in the rhizome of turmeric, has extensive therapeutic promise via its antioxidant, anti-inflammatory, and antiproliferative properties. Preclinical in vitro and in vivo data have shown it to be an effective treatment for brain tumors including glioblastoma multiforme. These effects are potentiated by curcumin's ability to induce G2/M cell cycle arrest, activation of apoptotic pathways, induction of autophagy, disruption of molecular signaling, inhibition of invasion, and metastasis and by increasing the efficacy of existing chemotherapeutics. Further, clinical data suggest that it has low toxicity in humans even at large doses. Curcumin is a promising nutraceutical compound that should be evaluated in clinical trials for the treatment of human brain tumors. Hindawi Publishing Corporation 2016 2016-10-11 /pmc/articles/PMC5078657/ /pubmed/27807473 http://dx.doi.org/10.1155/2016/9324085 Text en Copyright © 2016 N. V. Klinger and S. Mittal. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Klinger, Neil V. Mittal, Sandeep Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title | Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title_full | Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title_fullStr | Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title_full_unstemmed | Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title_short | Therapeutic Potential of Curcumin for the Treatment of Brain Tumors |
title_sort | therapeutic potential of curcumin for the treatment of brain tumors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078657/ https://www.ncbi.nlm.nih.gov/pubmed/27807473 http://dx.doi.org/10.1155/2016/9324085 |
work_keys_str_mv | AT klingerneilv therapeuticpotentialofcurcuminforthetreatmentofbraintumors AT mittalsandeep therapeuticpotentialofcurcuminforthetreatmentofbraintumors |