An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL

We report the case of a 26 year-old patient presenting with a persistent leukocytosis and CML-like marrow but no evidence of a BCR/ABL1 fusion. Molecular cytogenetics revealed that a portion of the ETV6 locus was inserted into the ABL1 locus. An ETV6/ABL1 fusion transcript could subsequently be conf...

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Detalles Bibliográficos
Autores principales: Kakadia, Purvi M., Schmidmaier, Ralf, Völkl, Andreas, Schneider, Irene, Huk, Natalia, Schneider, Stephanie, Panzner, Gerda, Neidel, Ulrike, Fritz, Barbara, Spiekermann, Karsten, Bohlander, Stefan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078675/
https://www.ncbi.nlm.nih.gov/pubmed/27812500
http://dx.doi.org/10.1016/j.lrr.2016.09.002

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