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Clinical characteristics of synchronous colorectal cancers in Japan

BACKGROUND: Incidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We stu...

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Autores principales: Kato, Takaharu, Alonso, Sergio, Muto, Yuta, Noda, Hiroshi, Miyakura, Yasuyuki, Suzuki, Koichi, Tsujinaka, Shingo, Saito, Masaaki, Perucho, Manuel, Rikiyama, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078884/
https://www.ncbi.nlm.nih.gov/pubmed/27776528
http://dx.doi.org/10.1186/s12957-016-1027-x
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author Kato, Takaharu
Alonso, Sergio
Muto, Yuta
Noda, Hiroshi
Miyakura, Yasuyuki
Suzuki, Koichi
Tsujinaka, Shingo
Saito, Masaaki
Perucho, Manuel
Rikiyama, Toshiki
author_facet Kato, Takaharu
Alonso, Sergio
Muto, Yuta
Noda, Hiroshi
Miyakura, Yasuyuki
Suzuki, Koichi
Tsujinaka, Shingo
Saito, Masaaki
Perucho, Manuel
Rikiyama, Toshiki
author_sort Kato, Takaharu
collection PubMed
description BACKGROUND: Incidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance. METHODS: We recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression. RESULTS: Eighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62). CONCLUSIONS: Our results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-016-1027-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-50788842016-10-31 Clinical characteristics of synchronous colorectal cancers in Japan Kato, Takaharu Alonso, Sergio Muto, Yuta Noda, Hiroshi Miyakura, Yasuyuki Suzuki, Koichi Tsujinaka, Shingo Saito, Masaaki Perucho, Manuel Rikiyama, Toshiki World J Surg Oncol Research BACKGROUND: Incidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance. METHODS: We recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression. RESULTS: Eighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62). CONCLUSIONS: Our results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-016-1027-x) contains supplementary material, which is available to authorized users. BioMed Central 2016-10-24 /pmc/articles/PMC5078884/ /pubmed/27776528 http://dx.doi.org/10.1186/s12957-016-1027-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Kato, Takaharu
Alonso, Sergio
Muto, Yuta
Noda, Hiroshi
Miyakura, Yasuyuki
Suzuki, Koichi
Tsujinaka, Shingo
Saito, Masaaki
Perucho, Manuel
Rikiyama, Toshiki
Clinical characteristics of synchronous colorectal cancers in Japan
title Clinical characteristics of synchronous colorectal cancers in Japan
title_full Clinical characteristics of synchronous colorectal cancers in Japan
title_fullStr Clinical characteristics of synchronous colorectal cancers in Japan
title_full_unstemmed Clinical characteristics of synchronous colorectal cancers in Japan
title_short Clinical characteristics of synchronous colorectal cancers in Japan
title_sort clinical characteristics of synchronous colorectal cancers in japan
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078884/
https://www.ncbi.nlm.nih.gov/pubmed/27776528
http://dx.doi.org/10.1186/s12957-016-1027-x
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