Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

BACKGROUND: Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we describe the preclinical and clinical results of a tran...

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Detalles Bibliográficos
Autores principales: Knox, Clayton D., de Kam, Pieter‐Jan, Azer, Karim, Wong, Peggy, Ederveen, Antwan G., Shevell, Diane, Morabito, Christopher, Meehan, Alan G., Liu, Wen, Reynders, Tom, Denef, Jean Francois, Mitselos, Anna, Jonathan, Daniel, Gutstein, David E., Mitra, Kaushik, Sun, Shu Yu, Lo, Michael Man‐Chu, Cully, Doris, Ali, Amjad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079016/
https://www.ncbi.nlm.nih.gov/pubmed/27561272
http://dx.doi.org/10.1161/JAHA.116.003493

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