Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes

BACKGROUND: Mutations in the coding sequence of SCN5A, which encodes the cardiac Na(+) channel α subunit, have been associated with inherited susceptibility to various arrhythmias. Variable expression of SCN5A is a possible mechanism responsible for this pleiotropic effect; however, it is unknown wh...

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Detalles Bibliográficos
Autores principales: Yagihara, Nobue, Watanabe, Hiroshi, Barnett, Phil, Duboscq‐Bidot, Laetitia, Thomas, Atack C., Yang, Ping, Ohno, Seiko, Hasegawa, Kanae, Kuwano, Ryozo, Chatel, Stéphanie, Redon, Richard, Schott, Jean‐Jacques, Probst, Vincent, Koopmann, Tamara T., Bezzina, Connie R., Wilde, Arthur A. M., Nakano, Yukiko, Aiba, Takeshi, Miyamoto, Yoshihiro, Kamakura, Shiro, Darbar, Dawood, Donahue, Brian S., Shigemizu, Daichi, Tanaka, Toshihiro, Tsunoda, Tatsuhiko, Suda, Masayoshi, Sato, Akinori, Minamino, Tohru, Endo, Naoto, Shimizu, Wataru, Horie, Minoru, Roden, Dan M., Makita, Naomasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079027/
https://www.ncbi.nlm.nih.gov/pubmed/27625342
http://dx.doi.org/10.1161/JAHA.116.003644

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