Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

BACKGROUND: We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule. By direct carbonylation modification of the Pro222 residue in the actuator (A) domain of pig Na/K‐ATPase α1 subunit, reactive oxy...

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Detalles Bibliográficos
Autores principales: Yan, Yanling, Shapiro, Anna P., Mopidevi, Brahma R., Chaudhry, Muhammad A., Maxwell, Kyle, Haller, Steven T., Drummond, Christopher A., Kennedy, David J., Tian, Jiang, Malhotra, Deepak, Xie, Zi‐jian, Shapiro, Joseph I., Liu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079028/
https://www.ncbi.nlm.nih.gov/pubmed/27613772
http://dx.doi.org/10.1161/JAHA.116.003675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079028/
https://www.ncbi.nlm.nih.gov/pubmed/27613772
http://dx.doi.org/10.1161/JAHA.116.003675

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