Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry

BACKGROUND: To clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. METHODS AND RESULTS: A consecutive series of outpatients with atr...

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Autores principales: Kodani, Eitaro, Atarashi, Hirotsugu, Inoue, Hiroshi, Okumura, Ken, Yamashita, Takeshi, Otsuka, Toshiaki, Tomita, Hirofumi, Origasa, Hideki, Sakurai, M., Kawamura, Y., Kubota, I., Kaneko, Y., Matsumoto, K., Ogawa, S., Aizawa, Y., Kodama, I., Watanabe, E., Koretsune, Y., Okuyama, Y., Shimizu, A., Igawa, O., Bando, S., Fukatani, M., Saikawa, T., Chishaki, A., Kato, N., Kanda, K., Kato, J., Obata, H., Aoki, M., Honda, H., Konta, Y., Hatayama, T., Abe, Y., Terata, K., Yagi, T., Ishida, A., Komatsu, T., Tachibana, H., Suzuki, H., Kamiyama, Y., Watanabe, T., Oguma, M., Itoh, M., Hirono, O., Tsunoda, Y., Ikeda, K., Kanaya, T., Sakurai, K., Sukekawa, H., Nakada, S., Itoh, T., Tange, S., Manita, M., Ohta, M., Eguma, H., Kato, R., Endo, Y., Ogino, T., Yamazaki, M., Kanki, H., Uchida, M., Miyanaga, S., Shibayama, K., Toratani, N., Kojima, T., Ichikawa, M., Saito, M., Umeda, Y., Sawanobori, T., Sohara, H., Okubo, S., Okubo, T., Tokunaga, T., Kuboyama, O., Ito, H., Kitahara, Y., Sagara, K., Satoh, T., Sugi, K., Kobayashi, Y., Higashi, Y., Katoh, T., Hirayama, Y., Matsumoto, N., Takano, M., Ikeda, T., Yusu, S., Niwano, S., Nakazato, Y., Kawano, Y., Sumiyoshi, M., Hagiwara, N., Murasaki, K., Mitamura, H., Nakagawa, S., Okishige, K., Azegami, K., Aoyagi, H., Sugiyama, K., Nishizaki, M., Yamawake, N., Watanabe, I., Ohkubo, K., Sakurada, H., Fukamizu, S., Suzuki, M., Nagahori, W., Nakamura, T., Murakawa, Y., Hayami, N., Yoshioka, K., Amino, M., Hirao, K., Yagishita, A., Ajiki, K., Fujiu, K., Imai, Y., Yamashina, A., Ishiyama, T., Sakabe, M., Nishida, K., Asanoi, H., Ueno, H., Lee, J. D., Mitsuke, Y., Furushima, H., Ebe, K., Tagawa, M., Sato, M., Morikawa, M., Yamashiro, K., Takami, K., Ozawa, T., Watarai, M., Yamauchi, M., Kamiya, H., Hirayama, H., Yoshida, Y., Murohara, T., Inden, Y., Osanai, H., Ohte, N., Goto, T., Morishima, I., Yamamoto, T., Fujii, E., Senga, M., Hayashi, H., Urushida, T., Takada, Y., Tsuboi, N., Noda, T., Hirose, T., Onodera, T., Kageyama, S., Osaka, T., Tomita, T., Shimada, K., Nomura, M., Izawa, H., Sugiura, A., Arakawa, T., Kimura, K., Mine, T., Makita, T., Mizuno, H., Kobori, A., Haruna, T., Takagi, M., Tanaka, N., Shimizu, H., Kurita, T., Motoki, K., Takeda, N., Kijima, Y., Ito, M., Nakata, A., Ueda, Y., Hirata, A., Kamakura, S., Satomi, K., Yamada, Y., Yoshiga, Y., Ogawa, H., Kimura, M., Hayano, T., Kinbara, T., Tatsuno, H., Harada, M., Kusano, K. F., Adachi, M., Yano, A., Sawaguchi, M., Yamasaki, J., Matsuura, T., Tanaka, Y., Moritani, H., Maki, T., Okada, S., Takechi, M., Hamada, T., Nishikado, A., Takagi, Y., Matsumoto, I., Soeki, T., Doi, Y., Okawa, M., Seo, H., Kitamura, S., Yamamoto, K., Akizawa, M., Kaname, N., Ando, S., Narita, S., Inou, T., Fukuizumi, Y., Saku, K., Ogawa, M., Urabe, Y., Ikeuchi, M., Harada, S., Yamabe, H., Imamura, Y., Yamanouchi, Y., Sadamatsu, K., Yoshida, K., Kubota, T., Takahashi, N., Makino, N., Higuchi, Y., Ooie, T., Iwao, T., Kitamura, K., Imamura, T., Maemura, K., Komiya, N., Hayano, M., Yoshida, H., Kumagai, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079049/
https://www.ncbi.nlm.nih.gov/pubmed/27620886
http://dx.doi.org/10.1161/JAHA.116.004075
_version_ 1782462506165338112
author Kodani, Eitaro
Atarashi, Hirotsugu
Inoue, Hiroshi
Okumura, Ken
Yamashita, Takeshi
Otsuka, Toshiaki
Tomita, Hirofumi
Origasa, Hideki
Sakurai, M.
Kawamura, Y.
Kubota, I.
Kaneko, Y.
Matsumoto, K.
Ogawa, S.
Aizawa, Y.
Kodama, I.
Watanabe, E.
Koretsune, Y.
Okuyama, Y.
Shimizu, A.
Igawa, O.
Bando, S.
Fukatani, M.
Saikawa, T.
Chishaki, A.
Kato, N.
Kanda, K.
Kato, J.
Obata, H.
Aoki, M.
Honda, H.
Konta, Y.
Hatayama, T.
Abe, Y.
Terata, K.
Yagi, T.
Ishida, A.
Komatsu, T.
Tachibana, H.
Suzuki, H.
Kamiyama, Y.
Watanabe, T.
Oguma, M.
Itoh, M.
Hirono, O.
Tsunoda, Y.
Ikeda, K.
Kanaya, T.
Sakurai, K.
Sukekawa, H.
Nakada, S.
Itoh, T.
Tange, S.
Manita, M.
Ohta, M.
Eguma, H.
Kato, R.
Endo, Y.
Ogino, T.
Yamazaki, M.
Kanki, H.
Uchida, M.
Miyanaga, S.
Shibayama, K.
Toratani, N.
Kojima, T.
Ichikawa, M.
Saito, M.
Umeda, Y.
Sawanobori, T.
Sohara, H.
Okubo, S.
Okubo, T.
Tokunaga, T.
Kuboyama, O.
Ito, H.
Kitahara, Y.
Sagara, K.
Satoh, T.
Sugi, K.
Kobayashi, Y.
Higashi, Y.
Katoh, T.
Hirayama, Y.
Matsumoto, N.
Takano, M.
Ikeda, T.
Yusu, S.
Niwano, S.
Nakazato, Y.
Kawano, Y.
Sumiyoshi, M.
Hagiwara, N.
Murasaki, K.
Mitamura, H.
Nakagawa, S.
Okishige, K.
Azegami, K.
Aoyagi, H.
Sugiyama, K.
Nishizaki, M.
Yamawake, N.
Watanabe, I.
Ohkubo, K.
Sakurada, H.
Fukamizu, S.
Suzuki, M.
Nagahori, W.
Nakamura, T.
Murakawa, Y.
Hayami, N.
Yoshioka, K.
Amino, M.
Hirao, K.
Yagishita, A.
Ajiki, K.
Fujiu, K.
Imai, Y.
Yamashina, A.
Ishiyama, T.
Sakabe, M.
Nishida, K.
Asanoi, H.
Ueno, H.
Lee, J. D.
Mitsuke, Y.
Furushima, H.
Ebe, K.
Tagawa, M.
Sato, M.
Morikawa, M.
Yamashiro, K.
Takami, K.
Ozawa, T.
Watarai, M.
Yamauchi, M.
Kamiya, H.
Hirayama, H.
Yoshida, Y.
Murohara, T.
Inden, Y.
Osanai, H.
Ohte, N.
Goto, T.
Morishima, I.
Yamamoto, T.
Fujii, E.
Senga, M.
Hayashi, H.
Urushida, T.
Takada, Y.
Tsuboi, N.
Noda, T.
Hirose, T.
Onodera, T.
Kageyama, S.
Osaka, T.
Tomita, T.
Shimada, K.
Nomura, M.
Izawa, H.
Sugiura, A.
Arakawa, T.
Kimura, K.
Mine, T.
Makita, T.
Mizuno, H.
Kobori, A.
Haruna, T.
Takagi, M.
Tanaka, N.
Shimizu, H.
Kurita, T.
Motoki, K.
Takeda, N.
Kijima, Y.
Ito, M.
Nakata, A.
Ueda, Y.
Hirata, A.
Kamakura, S.
Satomi, K.
Yamada, Y.
Yoshiga, Y.
Ogawa, H.
Kimura, M.
Hayano, T.
Kinbara, T.
Tatsuno, H.
Harada, M.
Kusano, K. F.
Adachi, M.
Yano, A.
Sawaguchi, M.
Yamasaki, J.
Matsuura, T.
Tanaka, Y.
Moritani, H.
Maki, T.
Okada, S.
Takechi, M.
Hamada, T.
Nishikado, A.
Takagi, Y.
Matsumoto, I.
Soeki, T.
Doi, Y.
Okawa, M.
Seo, H.
Kitamura, S.
Yamamoto, K.
Akizawa, M.
Kaname, N.
Ando, S.
Narita, S.
Inou, T.
Fukuizumi, Y.
Saku, K.
Ogawa, M.
Urabe, Y.
Ikeuchi, M.
Harada, S.
Yamabe, H.
Imamura, Y.
Yamanouchi, Y.
Sadamatsu, K.
Yoshida, K.
Kubota, T.
Takahashi, N.
Makino, N.
Higuchi, Y.
Ooie, T.
Iwao, T.
Kitamura, K.
Imamura, T.
Maemura, K.
Komiya, N.
Hayano, M.
Yoshida, H.
Kumagai, K.
author_facet Kodani, Eitaro
Atarashi, Hirotsugu
Inoue, Hiroshi
Okumura, Ken
Yamashita, Takeshi
Otsuka, Toshiaki
Tomita, Hirofumi
Origasa, Hideki
Sakurai, M.
Kawamura, Y.
Kubota, I.
Kaneko, Y.
Matsumoto, K.
Ogawa, S.
Aizawa, Y.
Kodama, I.
Watanabe, E.
Koretsune, Y.
Okuyama, Y.
Shimizu, A.
Igawa, O.
Bando, S.
Fukatani, M.
Saikawa, T.
Chishaki, A.
Kato, N.
Kanda, K.
Kato, J.
Obata, H.
Aoki, M.
Honda, H.
Konta, Y.
Hatayama, T.
Abe, Y.
Terata, K.
Yagi, T.
Ishida, A.
Komatsu, T.
Tachibana, H.
Suzuki, H.
Kamiyama, Y.
Watanabe, T.
Oguma, M.
Itoh, M.
Hirono, O.
Tsunoda, Y.
Ikeda, K.
Kanaya, T.
Sakurai, K.
Sukekawa, H.
Nakada, S.
Itoh, T.
Tange, S.
Manita, M.
Ohta, M.
Eguma, H.
Kato, R.
Endo, Y.
Ogino, T.
Yamazaki, M.
Kanki, H.
Uchida, M.
Miyanaga, S.
Shibayama, K.
Toratani, N.
Kojima, T.
Ichikawa, M.
Saito, M.
Umeda, Y.
Sawanobori, T.
Sohara, H.
Okubo, S.
Okubo, T.
Tokunaga, T.
Kuboyama, O.
Ito, H.
Kitahara, Y.
Sagara, K.
Satoh, T.
Sugi, K.
Kobayashi, Y.
Higashi, Y.
Katoh, T.
Hirayama, Y.
Matsumoto, N.
Takano, M.
Ikeda, T.
Yusu, S.
Niwano, S.
Nakazato, Y.
Kawano, Y.
Sumiyoshi, M.
Hagiwara, N.
Murasaki, K.
Mitamura, H.
Nakagawa, S.
Okishige, K.
Azegami, K.
Aoyagi, H.
Sugiyama, K.
Nishizaki, M.
Yamawake, N.
Watanabe, I.
Ohkubo, K.
Sakurada, H.
Fukamizu, S.
Suzuki, M.
Nagahori, W.
Nakamura, T.
Murakawa, Y.
Hayami, N.
Yoshioka, K.
Amino, M.
Hirao, K.
Yagishita, A.
Ajiki, K.
Fujiu, K.
Imai, Y.
Yamashina, A.
Ishiyama, T.
Sakabe, M.
Nishida, K.
Asanoi, H.
Ueno, H.
Lee, J. D.
Mitsuke, Y.
Furushima, H.
Ebe, K.
Tagawa, M.
Sato, M.
Morikawa, M.
Yamashiro, K.
Takami, K.
Ozawa, T.
Watarai, M.
Yamauchi, M.
Kamiya, H.
Hirayama, H.
Yoshida, Y.
Murohara, T.
Inden, Y.
Osanai, H.
Ohte, N.
Goto, T.
Morishima, I.
Yamamoto, T.
Fujii, E.
Senga, M.
Hayashi, H.
Urushida, T.
Takada, Y.
Tsuboi, N.
Noda, T.
Hirose, T.
Onodera, T.
Kageyama, S.
Osaka, T.
Tomita, T.
Shimada, K.
Nomura, M.
Izawa, H.
Sugiura, A.
Arakawa, T.
Kimura, K.
Mine, T.
Makita, T.
Mizuno, H.
Kobori, A.
Haruna, T.
Takagi, M.
Tanaka, N.
Shimizu, H.
Kurita, T.
Motoki, K.
Takeda, N.
Kijima, Y.
Ito, M.
Nakata, A.
Ueda, Y.
Hirata, A.
Kamakura, S.
Satomi, K.
Yamada, Y.
Yoshiga, Y.
Ogawa, H.
Kimura, M.
Hayano, T.
Kinbara, T.
Tatsuno, H.
Harada, M.
Kusano, K. F.
Adachi, M.
Yano, A.
Sawaguchi, M.
Yamasaki, J.
Matsuura, T.
Tanaka, Y.
Moritani, H.
Maki, T.
Okada, S.
Takechi, M.
Hamada, T.
Nishikado, A.
Takagi, Y.
Matsumoto, I.
Soeki, T.
Doi, Y.
Okawa, M.
Seo, H.
Kitamura, S.
Yamamoto, K.
Akizawa, M.
Kaname, N.
Ando, S.
Narita, S.
Inou, T.
Fukuizumi, Y.
Saku, K.
Ogawa, M.
Urabe, Y.
Ikeuchi, M.
Harada, S.
Yamabe, H.
Imamura, Y.
Yamanouchi, Y.
Sadamatsu, K.
Yoshida, K.
Kubota, T.
Takahashi, N.
Makino, N.
Higuchi, Y.
Ooie, T.
Iwao, T.
Kitamura, K.
Imamura, T.
Maemura, K.
Komiya, N.
Hayano, M.
Yoshida, H.
Kumagai, K.
author_sort Kodani, Eitaro
collection PubMed
description BACKGROUND: To clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. METHODS AND RESULTS: A consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihypertensive drug use. Hypertension was an independent risk factor for major hemorrhage (hazard ratio 1.52, 95% CI 1.05–2.21, P=0.027) but not for thromboembolism (hazard ratio 1.05, 95% CI 0.73–1.52, P=0.787). When patients were divided into quartiles according to their systolic BP at the time closest to the event or at the end of follow‐up (Q1, <114; Q2, 114–125; Q3, 126–135; and Q4, ≥136 mm Hg), odds ratios for both events were significantly higher in Q4 than in Q1 (thromboembolism, odds ratio 2.88, 95% CI 1.75–4.74, P<0.001; major hemorrhage, odds ratio 1.61, 95% CI 1.02–2.53, P=0.041) after adjustment for components of CHA (2) DS (2)‐VASc score, warfarin use, and antiplatelet use. A systolic BP of ≥136 mm Hg was an independent risk factor for thromboembolism and major hemorrhage. CONCLUSIONS: BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. CLINICAL TRIAL REGISTRATION: URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000001569.
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spelling pubmed-50790492016-10-28 Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry Kodani, Eitaro Atarashi, Hirotsugu Inoue, Hiroshi Okumura, Ken Yamashita, Takeshi Otsuka, Toshiaki Tomita, Hirofumi Origasa, Hideki Sakurai, M. Kawamura, Y. Kubota, I. Kaneko, Y. Matsumoto, K. Ogawa, S. Aizawa, Y. Kodama, I. Watanabe, E. Koretsune, Y. Okuyama, Y. Shimizu, A. Igawa, O. Bando, S. Fukatani, M. Saikawa, T. Chishaki, A. Kato, N. Kanda, K. Kato, J. Obata, H. Aoki, M. Honda, H. Konta, Y. Hatayama, T. Abe, Y. Terata, K. Yagi, T. Ishida, A. Komatsu, T. Tachibana, H. Suzuki, H. Kamiyama, Y. Watanabe, T. Oguma, M. Itoh, M. Hirono, O. Tsunoda, Y. Ikeda, K. Kanaya, T. Sakurai, K. Sukekawa, H. Nakada, S. Itoh, T. Tange, S. Manita, M. Ohta, M. Eguma, H. Kato, R. Endo, Y. Ogino, T. Yamazaki, M. Kanki, H. Uchida, M. Miyanaga, S. Shibayama, K. Toratani, N. Kojima, T. Ichikawa, M. Saito, M. Umeda, Y. Sawanobori, T. Sohara, H. Okubo, S. Okubo, T. Tokunaga, T. Kuboyama, O. Ito, H. Kitahara, Y. Sagara, K. Satoh, T. Sugi, K. Kobayashi, Y. Higashi, Y. Katoh, T. Hirayama, Y. Matsumoto, N. Takano, M. Ikeda, T. Yusu, S. Niwano, S. Nakazato, Y. Kawano, Y. Sumiyoshi, M. Hagiwara, N. Murasaki, K. Mitamura, H. Nakagawa, S. Okishige, K. Azegami, K. Aoyagi, H. Sugiyama, K. Nishizaki, M. Yamawake, N. Watanabe, I. Ohkubo, K. Sakurada, H. Fukamizu, S. Suzuki, M. Nagahori, W. Nakamura, T. Murakawa, Y. Hayami, N. Yoshioka, K. Amino, M. Hirao, K. Yagishita, A. Ajiki, K. Fujiu, K. Imai, Y. Yamashina, A. Ishiyama, T. Sakabe, M. Nishida, K. Asanoi, H. Ueno, H. Lee, J. D. Mitsuke, Y. Furushima, H. Ebe, K. Tagawa, M. Sato, M. Morikawa, M. Yamashiro, K. Takami, K. Ozawa, T. Watarai, M. Yamauchi, M. Kamiya, H. Hirayama, H. Yoshida, Y. Murohara, T. Inden, Y. Osanai, H. Ohte, N. Goto, T. Morishima, I. Yamamoto, T. Fujii, E. Senga, M. Hayashi, H. Urushida, T. Takada, Y. Tsuboi, N. Noda, T. Hirose, T. Onodera, T. Kageyama, S. Osaka, T. Tomita, T. Shimada, K. Nomura, M. Izawa, H. Sugiura, A. Arakawa, T. Kimura, K. Mine, T. Makita, T. Mizuno, H. Kobori, A. Haruna, T. Takagi, M. Tanaka, N. Shimizu, H. Kurita, T. Motoki, K. Takeda, N. Kijima, Y. Ito, M. Nakata, A. Ueda, Y. Hirata, A. Kamakura, S. Satomi, K. Yamada, Y. Yoshiga, Y. Ogawa, H. Kimura, M. Hayano, T. Kinbara, T. Tatsuno, H. Harada, M. Kusano, K. F. Adachi, M. Yano, A. Sawaguchi, M. Yamasaki, J. Matsuura, T. Tanaka, Y. Moritani, H. Maki, T. Okada, S. Takechi, M. Hamada, T. Nishikado, A. Takagi, Y. Matsumoto, I. Soeki, T. Doi, Y. Okawa, M. Seo, H. Kitamura, S. Yamamoto, K. Akizawa, M. Kaname, N. Ando, S. Narita, S. Inou, T. Fukuizumi, Y. Saku, K. Ogawa, M. Urabe, Y. Ikeuchi, M. Harada, S. Yamabe, H. Imamura, Y. Yamanouchi, Y. Sadamatsu, K. Yoshida, K. Kubota, T. Takahashi, N. Makino, N. Higuchi, Y. Ooie, T. Iwao, T. Kitamura, K. Imamura, T. Maemura, K. Komiya, N. Hayano, M. Yoshida, H. Kumagai, K. J Am Heart Assoc Original Research BACKGROUND: To clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. METHODS AND RESULTS: A consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihypertensive drug use. Hypertension was an independent risk factor for major hemorrhage (hazard ratio 1.52, 95% CI 1.05–2.21, P=0.027) but not for thromboembolism (hazard ratio 1.05, 95% CI 0.73–1.52, P=0.787). When patients were divided into quartiles according to their systolic BP at the time closest to the event or at the end of follow‐up (Q1, <114; Q2, 114–125; Q3, 126–135; and Q4, ≥136 mm Hg), odds ratios for both events were significantly higher in Q4 than in Q1 (thromboembolism, odds ratio 2.88, 95% CI 1.75–4.74, P<0.001; major hemorrhage, odds ratio 1.61, 95% CI 1.02–2.53, P=0.041) after adjustment for components of CHA (2) DS (2)‐VASc score, warfarin use, and antiplatelet use. A systolic BP of ≥136 mm Hg was an independent risk factor for thromboembolism and major hemorrhage. CONCLUSIONS: BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. CLINICAL TRIAL REGISTRATION: URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000001569. John Wiley and Sons Inc. 2016-09-12 /pmc/articles/PMC5079049/ /pubmed/27620886 http://dx.doi.org/10.1161/JAHA.116.004075 Text en © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kodani, Eitaro
Atarashi, Hirotsugu
Inoue, Hiroshi
Okumura, Ken
Yamashita, Takeshi
Otsuka, Toshiaki
Tomita, Hirofumi
Origasa, Hideki
Sakurai, M.
Kawamura, Y.
Kubota, I.
Kaneko, Y.
Matsumoto, K.
Ogawa, S.
Aizawa, Y.
Kodama, I.
Watanabe, E.
Koretsune, Y.
Okuyama, Y.
Shimizu, A.
Igawa, O.
Bando, S.
Fukatani, M.
Saikawa, T.
Chishaki, A.
Kato, N.
Kanda, K.
Kato, J.
Obata, H.
Aoki, M.
Honda, H.
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Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title_full Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title_fullStr Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title_full_unstemmed Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title_short Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry
title_sort impact of blood pressure control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation: a subanalysis of the j‐rhythm registry
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079049/
https://www.ncbi.nlm.nih.gov/pubmed/27620886
http://dx.doi.org/10.1161/JAHA.116.004075
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AT yoshiday impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT muroharat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT indeny impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT osanaih impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ohten impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT gotot impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT morishimai impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamamotot impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT fujiie impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT sengam impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hayashih impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT urushidat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takaday impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT tsuboin impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT nodat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hiroset impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT onoderat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kageyamas impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT osakat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT tomitat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT shimadak impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT nomuram impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT izawah impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT sugiuraa impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT arakawat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kimurak impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT minet impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT makitat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT mizunoh impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT koboria impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT harunat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takagim impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT tanakan impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT shimizuh impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kuritat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT motokik impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takedan impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kijimay impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT itom impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT nakataa impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ueday impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hirataa impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kamakuras impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT satomik impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamaday impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yoshigay impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ogawah impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kimuram impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hayanot impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kinbarat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT tatsunoh impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT haradam impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kusanokf impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT adachim impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yanoa impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT sawaguchim impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamasakij impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT matsuurat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT tanakay impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT moritanih impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT makit impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT okadas impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takechim impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hamadat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT nishikadoa impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takagiy impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT matsumotoi impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT soekit impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT doiy impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT okawam impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT seoh impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kitamuras impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamamotok impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT akizawam impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kanamen impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT andos impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT naritas impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT inout impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT fukuizumiy impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT sakuk impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ogawam impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT urabey impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ikeuchim impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT haradas impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamabeh impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT imamuray impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yamanouchiy impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT sadamatsuk impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yoshidak impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kubotat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT takahashin impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT makinon impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT higuchiy impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT ooiet impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT iwaot impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kitamurak impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT imamurat impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT maemurak impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT komiyan impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT hayanom impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT yoshidah impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry
AT kumagaik impactofbloodpressurecontrolonthromboembolismandmajorhemorrhageinpatientswithnonvalvularatrialfibrillationasubanalysisofthejrhythmregistry

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