Hydrogen Sulfide Regulates Krüppel‐Like Factor 5 Transcription Activity via Specificity Protein 1 S‐Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy

BACKGROUND: Hydrogen sulfide (H(2)S) is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel‐like factor 5 (KLF5) exerts diverse functions in the cardiovascular system. Whether and how H(2)S regulates KLF5 in myocardial hypertrophy is unknown. METHODS AND RESULTS: In our study...

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Detalles Bibliográficos
Autores principales: Meng, Guoliang, Xiao, Yujiao, Ma, Yan, Tang, Xin, Xie, Liping, Liu, Jieqiong, Gu, Yue, Yu, Ying, Park, Chung‐Min, Xian, Ming, Wang, Xin, Ferro, Albert, Wang, Rui, Moore, Philip K., Zhang, Zhiren, Wang, Hong, Han, Yi, Ji, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079055/
https://www.ncbi.nlm.nih.gov/pubmed/27638782
http://dx.doi.org/10.1161/JAHA.116.004160

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