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The Role of Local Ancestry Adjustment in Association Studies Using Admixed Populations

1. For causal variants with similar effect size in all populations, power is generally higher in a study using admixed population than using nonadmixed population, especially for highly differentiated SNPs. This gain of power is achieved with adjustment of global ancestry, which completely removes a...

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Detalles Bibliográficos
Autores principales: Zhang, Jianqi, Stram, Daniel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079159/
https://www.ncbi.nlm.nih.gov/pubmed/25043967
http://dx.doi.org/10.1002/gepi.21835

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