Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides

[Image: see text] Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was show...

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Autores principales: Huang, Liangbin, Weix, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079292/
https://www.ncbi.nlm.nih.gov/pubmed/27736085
http://dx.doi.org/10.1021/acs.orglett.6b02862
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author Huang, Liangbin
Weix, Daniel J.
author_facet Huang, Liangbin
Weix, Daniel J.
author_sort Huang, Liangbin
collection PubMed
description [Image: see text] Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C–H bond.
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spelling pubmed-50792922017-10-13 Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides Huang, Liangbin Weix, Daniel J. Org Lett [Image: see text] Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C–H bond. American Chemical Society 2016-10-13 2016-10-21 /pmc/articles/PMC5079292/ /pubmed/27736085 http://dx.doi.org/10.1021/acs.orglett.6b02862 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Huang, Liangbin
Weix, Daniel J.
Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title_full Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title_fullStr Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title_full_unstemmed Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title_short Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides
title_sort ruthenium-catalyzed c–h arylation of diverse aryl carboxylic acids with aryl and heteroaryl halides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079292/
https://www.ncbi.nlm.nih.gov/pubmed/27736085
http://dx.doi.org/10.1021/acs.orglett.6b02862
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AT weixdanielj rutheniumcatalyzedcharylationofdiversearylcarboxylicacidswitharylandheteroarylhalides

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